TNF Receptor Associated Factor 1 (TRAF1)

EBI6; Epstein-Barr Virus Induced Protein 6

SPN	Q742
HGNC	12031
MGI	101836
PubMed	17804836
UniProt	Q13077
Wiki	TRAF1

TRAF1is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.

Reference

"The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family."
Cell 80:389-399(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor."
Cell 78:681-692(1994) [PubMed] [Europe PMC] [Abstract]

"I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction."
Proc. Natl. Acad. Sci. U.S.A. 93:8241-8246(1996) [PubMed] [Europe PMC] [Abstract]

"T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors."
J. Exp. Med. 183:669-674(1996) [PubMed] [Europe PMC] [Abstract]

"CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization."
Biochemistry 37:11836-11845(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of CARDIAK, a RIP-like kinase that associates with caspase-1."
Curr. Biol. 8:885-888(1998) [PubMed] [Europe PMC] [Abstract]

"RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase."
J. Biol. Chem. 273:16968-16975(1998) [PubMed] [Europe PMC] [Abstract]

"The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor."
J. Biol. Chem. 273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract]

"CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand."
J. Exp. Med. 187:1849-1862(1998) [PubMed] [Europe PMC] [Abstract]

"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB."
Mol. Cell. Biol. 18:558-565(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand."
J. Biol. Chem. 274:6056-6061(1999) [PubMed] [Europe PMC] [Abstract]

"Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis."
FEBS Lett. 468:129-133(2000) [PubMed] [Europe PMC] [Abstract]

"TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."
J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]

"TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase."
J. Immunol. 165:1322-1330(2000) [PubMed] [Europe PMC] [Abstract]

"RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB."
Blood 97:2702-2707(2001) [PubMed] [Europe PMC] [Abstract]

"The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A."
J. Biol. Chem. 276:2668-2677(2001) [PubMed] [Europe PMC] [Abstract]

"TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2."
Nature 416:345-347(2002) [PubMed] [Europe PMC] [Abstract]

"TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation."
J. Biol. Chem. 279:55855-55865(2004) [PubMed] [Europe PMC] [Abstract]

"Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2."
Proteomics 4:3376-3382(2004) [PubMed] [Europe PMC] [Abstract]

"TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling."
Eur. J. Immunol. 36:199-206(2006) [PubMed] [Europe PMC] [Abstract]

"Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1."
Genes Cells 13:509-520(2008) [PubMed] [Europe PMC] [Abstract]

"TNF receptor-associated factor 1 is a positive regulator of the NF-kappaB alternative pathway."
Mol. Immunol. 46:3278-3282(2009) [PubMed] [Europe PMC] [Abstract]

"Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation."
Oncogene 28:1769-1781(2009) [PubMed] [Europe PMC] [Abstract]

"Asymmetric recruitment of cIAPs by TRAF2."
J. Mol. Biol. 400:8-15(2010) [PubMed] [Europe PMC] [Abstract]

"Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation."
Mol. Cell. Biochem. 338:11-17(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation."
Mol. Cell 38:101-113(2010) [PubMed] [Europe PMC] [Abstract]

"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]