Clathrin, Light Polypeptide B (CLTB)

Lcb

SPN	Q721
HGNC	2091
MGI	1921575
RGD	621353
UniProt	P09497

Clathrin is the main structural component of the lattice covering the cytoplasmic face of the coated pits and coated vesicles in which specific macromolecules are entrapped in the process of receptor-mediated endocytosis. Clathrin is a large, soluble protein composed of heavy chains (molecular size, about 192 kD) and light chains (molecular size, about 32 to 38 kD). Two major classes of clathrin light chains, referred to as LCA (encoded by the CLTA gene) and LCB (encoded by CTLB), have been identified.

By Southern blot analysis carried out on genomic DNA extracted from a panel of mouse-human somatic cell hybrids and by isotopic in situ hybridization, Ponnambalam et al. (1994) assigned the CLTB gene to human 4q2-q3.

Reference

"Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species."
J. Biol. Chem. 263:16688-16695(1988) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain."
J. Biol. Chem. 277:19897-19904(2002) [PubMed] [Europe PMC] [Abstract]

"Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo."
J. Biol. Chem. 280:6109-6117(2005) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]