Adaptor Related Protein Complex 2 Mu 1 (AP2m1)

AP50; CLAPM1; Clathrin-Associated/Assembly/Adaptor Protein,Medium 1; Plasma Membrane Adaptor AP-2 50kDA Protein; Clathrin Coat Adaptor Protein AP50

SPN	Q705
HGNC	564
MGI	1298405
PubMed	22916011
RGD	620135
UniProt	Q96CW1
Wiki	AP2M1

AP2m1 encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.AP50 is a 50-kD component of the AP2 coat assembly protein complex of clathrin-coated vesicles. The complex consists of 2 large 100-kD components, which are called the alpha and beta subunits, a 50-kD component (AP50), and a small 17-kD protein.

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