Call Now

Amyloid Beta Precursor Like Protein 2 (APLP2)

APPH; APPL2; CDEBP; Amyloid protein homolog; CDEI box-binding protein

APLP2 associates with antigen presentation molecules like MHC class I molecules and regulates their surface expression by enhancing endocytosis.May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.In placenta, brain, heart, lung, liver, kidney and endothelial tissues.
APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ690Hu01 Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ690Hu01 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
PAQ690Hu01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IF.
Assay Kits CLQ690Hu01 CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA assay for Antigen Detection
ELQ690Hu01 ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ690Mu01 Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ690Mu01 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
PAQ690Mu01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IF.
Assay Kits CLQ690Mu01 CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA assay for Antigen Detection
ELQ690Mu01 ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ690Ra01 Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ690Ra01 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
PAQ690Ra01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IF.
Assay Kits CLQ690Ra01 CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA assay for Antigen Detection
ELQ690Ra01 ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ690Ca01 Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ690Ca01 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
PAQ690Ca01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IF.
Assay Kits CLQ690Ca01 CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA assay for Antigen Detection
ELQ690Ca01 ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ690Po01 Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ690Po01 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
PAQ690Po01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IF.
Assay Kits CLQ690Po01 CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA assay for Antigen Detection
ELQ690Po01 ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ690Bo01 Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ690Bo01 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
PAQ690Bo01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IF.
Assay Kits CLQ690Bo01 CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA assay for Antigen Detection
ELQ690Bo01 ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ690Rb01 Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ690Rb01 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
PAQ690Rb01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IF.
Assay Kits CLQ690Rb01 CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA assay for Antigen Detection
ELQ690Rb01 ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ690Mo01 Recombinant Amyloid Beta Precursor Like Protein 2 (APLP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ690Mo01 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IP.
PAQ690Mo01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2) WB; IHC; ICC; IF.
Assay Kits CLQ690Mo01 CLIA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) CLIA assay for Antigen Detection
ELQ690Mo01 ELISA Kit for Amyloid Beta Precursor Like Protein 2 (APLP2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family."
Biochemistry 32:4481-4486(1993) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor."
Nat. Genet. 5:95-99(1993) [PubMed] [Europe PMC] [Abstract]

"A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein."
DNA Cell Biol. 13:1137-1143(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"USF binds to the APB alpha sequence in the promoter of the amyloid beta-protein precursor gene."
Nucleic Acids Res. 23:2734-2741(1995) [PubMed] [Europe PMC] [Abstract]

"Expression and characterization of the human YWK-II gene, encoding a sperm membrane protein related to the alzheimer betaA4-amyloid precursor protein."
Mol. Hum. Reprod. 6:1069-1078(2000) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression, purification and characterization of a Kunitz-type protease inhibitor domain from human amyloid precursor protein homolog."
FEBS Lett. 338:53-57(1994) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]