X-Ray Repair Cross Complementing 2 (XRCC2)

DNA repair protein XRCC2

SPN	Q665
HGNC	12829
MGI	1927345
PubMed	22464251
RGD	1564823
UniProt	O43543
Wiki	XRCC2

XRCC2participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.Hamster cells deficient in XRCC2 showed a more than 100-fold decrease in homologous recombination induced by double-strand breaks compared with the parental cell line. This defect was corrected to almost wildtype levels by transient transfection with a plasmid expressing XRCC2. The repair defect in XRCC2 mutant cells appeared to be restricted to recombinational repair because nonhomologous end joining was normal.

Reference

"XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages."
Mol. Cell 1:783-793(1998) [PubMed] [Europe PMC] [Abstract]

"The XRCC2 DNA repair gene: identification of a positional candidate."
Genomics 41:84-92(1997) [PubMed] [Europe PMC] [Abstract]

"The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family."
Nucleic Acids Res. 26:3084-3089(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification and purification of two distinct complexes containing the five RAD51 paralogs."
Genes Dev. 15:3296-3307(2001) [PubMed] [Europe PMC] [Abstract]

"RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51."
J. Biol. Chem. 277:8406-8411(2002) [PubMed] [Europe PMC] [Abstract]

"Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex."
J. Biol. Chem. 277:14315-14320(2002) [PubMed] [Europe PMC] [Abstract]

"Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells."
Nucleic Acids Res. 30:1001-1008(2002) [PubMed] [Europe PMC] [Abstract]

"Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells."
Nucleic Acids Res. 30:1009-1015(2002) [PubMed] [Europe PMC] [Abstract]

"Domain mapping of the Rad51 paralog protein complexes."
Nucleic Acids Res. 32:169-178(2004) [PubMed] [Europe PMC] [Abstract]

"Homologous recombination proteins are associated with centrosomes and are required for mitotic stability."
Exp. Cell Res. 317:1203-1213(2011) [PubMed] [Europe PMC] [Abstract]

"Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway."
Mol. Cell. Biol. 33:387-395(2013) [PubMed] [Europe PMC] [Abstract]

"Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy."
J. Biol. Chem. 285:13349-13356(2010) [PubMed] [Europe PMC] [Abstract]