Importin 8 (IPO8)
RANBP8; RAN Binding Protein 8
- Importin 8 is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase.
- Human RANBP8 and Xenopus RanBP7 share 61% amino acid identity. They both belong to a Ran-binding protein superfamily whose members share with importin-beta an N-terminal sequence motif that appears to account for RanGTP binding. IPO8 was required for AGO2 binding to a large set of target mRNAs, and knockdown of IPO8 led to a moderate increase of target mRNAs. Knockdown of IPO8 had no effect on AGO stability, miRNA biogenesis, or miRNA loading onto AGO proteins.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ663Hu01 | Recombinant Importin 8 (IPO8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ663Hu01 | Monoclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IP. |
| PAQ663Hu01 | Polyclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ663Hu01 | CLIA Kit for Importin 8 (IPO8) | CLIA assay for Antigen Detection |
| ELQ663Hu01 | ELISA Kit for Importin 8 (IPO8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ663Mu01 | Recombinant Importin 8 (IPO8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ663Mu01 | Monoclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IP. |
| PAQ663Mu01 | Polyclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ663Mu01 | CLIA Kit for Importin 8 (IPO8) | CLIA assay for Antigen Detection |
| ELQ663Mu01 | ELISA Kit for Importin 8 (IPO8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ663Ra01 | Recombinant Importin 8 (IPO8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ663Ra01 | Monoclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IP. |
| PAQ663Ra01 | Polyclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ663Ra01 | CLIA Kit for Importin 8 (IPO8) | CLIA assay for Antigen Detection |
| ELQ663Ra01 | ELISA Kit for Importin 8 (IPO8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ663Ca01 | Recombinant Importin 8 (IPO8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ663Ca01 | Monoclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IP. |
| PAQ663Ca01 | Polyclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ663Ca01 | CLIA Kit for Importin 8 (IPO8) | CLIA assay for Antigen Detection |
| ELQ663Ca01 | ELISA Kit for Importin 8 (IPO8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ663Po01 | Recombinant Importin 8 (IPO8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ663Po01 | Monoclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IP. |
| PAQ663Po01 | Polyclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ663Po01 | CLIA Kit for Importin 8 (IPO8) | CLIA assay for Antigen Detection |
| ELQ663Po01 | ELISA Kit for Importin 8 (IPO8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ663Bo01 | Recombinant Importin 8 (IPO8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ663Bo01 | Monoclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IP. |
| PAQ663Bo01 | Polyclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ663Bo01 | CLIA Kit for Importin 8 (IPO8) | CLIA assay for Antigen Detection |
| ELQ663Bo01 | ELISA Kit for Importin 8 (IPO8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ663Rb01 | Recombinant Importin 8 (IPO8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ663Rb01 | Monoclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IP. |
| PAQ663Rb01 | Polyclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ663Rb01 | CLIA Kit for Importin 8 (IPO8) | CLIA assay for Antigen Detection |
| ELQ663Rb01 | ELISA Kit for Importin 8 (IPO8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ663Mo01 | Recombinant Importin 8 (IPO8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ663Mo01 | Monoclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IP. |
| PAQ663Mo01 | Polyclonal Antibody to Importin 8 (IPO8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ663Mo01 | CLIA Kit for Importin 8 (IPO8) | CLIA assay for Antigen Detection |
| ELQ663Mo01 | ELISA Kit for Importin 8 (IPO8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A novel class of RanGTP binding proteins."
J. Cell Biol. 138:65-80(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin."
J. Cell Sci. 114:3479-3485(2001) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]