Discs, Large Homolog 4 (DLG4)

PSD95; SAP90; Postsynaptic density protein 95; Synapse-associated protein 90

SPN	Q639
HGNC	2903
MGI	1277959
PubMed	20952458
RGD	68424
UniProt	P78352
Wiki	DLG4

Disks large homolog 4 is a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with DLG2. With DLG2 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins.

Reference

"Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues."
Genomics 44:71-82(1997) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of human DLG4, the gene encoding postsynaptic density 95."
J. Neurochem. 73:2250-2265(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases."
Nature 378:85-88(1995) [PubMed] [Europe PMC] [Abstract]

"Binding of neuroligins to PSD-95."
Science 277:1511-1515(1997) [PubMed] [Europe PMC] [Abstract]

"GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes."
J. Biol. Chem. 275:28774-28784(2000) [PubMed] [Europe PMC] [Abstract]

"The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses."
Proc. Natl. Acad. Sci. U.S.A. 97:3596-3601(2000) [PubMed] [Europe PMC] [Abstract]

"Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms."
J. Neurosci. 22:6415-6425(2002) [PubMed] [Europe PMC] [Abstract]

"SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses."
Neuron 50:233-245(2006) [PubMed] [Europe PMC] [Abstract]

"Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis."
J. Neurosci. 28:14546-14556(2008) [PubMed] [Europe PMC] [Abstract]

"The PDZ1 domain of SAP90. Characterization of structure and binding."
J. Biol. Chem. 277:6967-6973(2002) [PubMed] [Europe PMC] [Abstract]