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Dedicator Of Cytokinesis 2 (DOCK2)

Dock2 is part of a large class of proteins (GEFs) which contibrute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to Guanosine diphosphate (GDP) and their activation requires the dissociation of GDP and binding of guanosine triphosphate (GTP). GEFs activate G proteins by promoting this nucleotide exchange.
Dock2 and other DOCK family proteins differ from other GEFs in that they do not possess the canonical structure of tandem DH-PH domains known to elicit nucleotide exchange. Instead they possess a DHR2 domain which mediates Rac activation by stabilising it in its nucleotide-free state. They also contain a DHR1 domain which binds phospholipids and is required for the interaction between Dock2 and the plasma membrane.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins Q625Hu01 Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
PQ625Hu01 Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dedicator Of Cytokinesis 2 (DOCK2) Bioactivity
Antibodies NONE Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA assay for Antigen Detection

Reference

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"DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines."
Blood 100:3968-3974(2002) [PubMed] [Europe PMC] [Abstract]

"DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription."
Biochem. Biophys. Res. Commun. 296:716-720(2002) [PubMed] [Europe PMC] [Abstract]

"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
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"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
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"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
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"Initial characterization of the human central proteome."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The solution structure of human DOCK2 SH3 domain - ELMO1 peptide chimera complex."
Submitted (OCT-2010) to the PDB data bank

"Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors."
J. Biol. Chem. 286:25341-25351(2011) [PubMed] [Europe PMC] [Abstract]