Calsyntenin 2 (CLSTN2)
CSTN2; CS2; CDHR13; Cadherin-Related Family Member 13; Alcadein-gamma
The deduced 955-amino acid protein contains an N-terminal signal sequence, followed by 2 cadherin repeats, a C-terminal transmembrane domain, and a cytoplasmic C terminus.
CLSTN2 shares 58% amino acid identity with CLSTN1 and 94% identity with its mouse homolog. Northern blot analysis of human tissues detected a 5-kb transcript expressed exclusively in brain. In situ hybridization showed nonuniform Clstn2 expression in the majority of adult mouse brain regions. In cerebral cortex, Clstn2 was found in the somas and neuropil of all layers, with highest immunoreactivity in cortical layers 5 and 6. Immunoelectron microscopy showed that Clstn2 was prominently expressed in postsynaptic specializations of asymmetric synapses.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ609Hu01 | Recombinant Calsyntenin 2 (CLSTN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ609Hu01 | Monoclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IP. |
| PAQ609Hu01 | Polyclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ609Hu01 | CLIA Kit for Calsyntenin 2 (CLSTN2) | CLIA assay for Antigen Detection |
| ELQ609Hu01 | ELISA Kit for Calsyntenin 2 (CLSTN2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ609Mu01 | Recombinant Calsyntenin 2 (CLSTN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ609Mu01 | Monoclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IP. |
| PAQ609Mu01 | Polyclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ609Mu01 | CLIA Kit for Calsyntenin 2 (CLSTN2) | CLIA assay for Antigen Detection |
| ELQ609Mu01 | ELISA Kit for Calsyntenin 2 (CLSTN2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ609Ra01 | Recombinant Calsyntenin 2 (CLSTN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ609Ra01 | Monoclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IP. |
| PAQ609Ra01 | Polyclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ609Ra01 | CLIA Kit for Calsyntenin 2 (CLSTN2) | CLIA assay for Antigen Detection |
| ELQ609Ra01 | ELISA Kit for Calsyntenin 2 (CLSTN2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ609Ca01 | Recombinant Calsyntenin 2 (CLSTN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ609Ca01 | Monoclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IP. |
| PAQ609Ca01 | Polyclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ609Ca01 | CLIA Kit for Calsyntenin 2 (CLSTN2) | CLIA assay for Antigen Detection |
| ELQ609Ca01 | ELISA Kit for Calsyntenin 2 (CLSTN2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ609Po01 | Recombinant Calsyntenin 2 (CLSTN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ609Po01 | Monoclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IP. |
| PAQ609Po01 | Polyclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ609Po01 | CLIA Kit for Calsyntenin 2 (CLSTN2) | CLIA assay for Antigen Detection |
| ELQ609Po01 | ELISA Kit for Calsyntenin 2 (CLSTN2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ609Bo01 | Recombinant Calsyntenin 2 (CLSTN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ609Bo01 | Monoclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IP. |
| PAQ609Bo01 | Polyclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ609Bo01 | CLIA Kit for Calsyntenin 2 (CLSTN2) | CLIA assay for Antigen Detection |
| ELQ609Bo01 | ELISA Kit for Calsyntenin 2 (CLSTN2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ609Rb01 | Recombinant Calsyntenin 2 (CLSTN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ609Rb01 | Monoclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IP. |
| PAQ609Rb01 | Polyclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ609Rb01 | CLIA Kit for Calsyntenin 2 (CLSTN2) | CLIA assay for Antigen Detection |
| ELQ609Rb01 | ELISA Kit for Calsyntenin 2 (CLSTN2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ609Mo01 | Recombinant Calsyntenin 2 (CLSTN2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ609Mo01 | Monoclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IP. |
| PAQ609Mo01 | Polyclonal Antibody to Calsyntenin 2 (CLSTN2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ609Mo01 | CLIA Kit for Calsyntenin 2 (CLSTN2) | CLIA assay for Antigen Detection |
| ELQ609Mo01 | ELISA Kit for Calsyntenin 2 (CLSTN2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The calsyntenins - a family of postsynaptic membrane proteins with distinct neuronal expression patterns."
Mol. Cell. Neurosci. 21:393-409(2002) [PubMed] [Europe PMC] [Abstract]
"Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism."
J. Biol. Chem. 278:49448-49458(2003) [PubMed] [Europe PMC] [Abstract]
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Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation."
J. Biol. Chem. 279:24343-24354(2004) [PubMed] [Europe PMC] [Abstract]
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Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]