Call Now

Proteoglycan 4 (PRG4)

MSF; CACP; HAPO; JCAP; SZP; Megakaryocyte Stimulating factor; Articular Superficial Zone Protein; Camptodactyly; Arthropathy,Coxa Vara,Pericarditis Syndrome

Proteoglycan 4 is an approximately 345-kD proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. The cDNA encodes a protein of 1,404 amino acids with a somatomedin B homology domain, heparin-binding domains, multiple mucin-like repeats, a hemopexin domain, and an aggregation domain. There are 3 consensus sequences for N-glycosylation and 1 chondroitin sulfate substitution site. The locus for autosomal recessive camptodactyly-arthropathy-coxa vara-pericarditis syndrome maps to chromosome 1q25-q31. This protein may act as a joint/intimal cell lubricant, and cell overgrowth may be primary to the pathogenesis of this protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins Q561Hu01 Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies MQ561Hu21 Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
PQ561Hu01 Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits KEQ561Hu ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits KEQ561Mu ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Proteoglycan 4 (PRG4) Bioactivity
Antibodies NONE Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Proteoglycan 4 (PRG4) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Proteoglycan 4 (PRG4) CLIA assay for Antigen Detection

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism."
Biochem. Biophys. Res. Commun. 254:535-541(1999) [PubMed] [Europe PMC] [Abstract]

"Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages."
Blood 103:4449-4456(2004) [PubMed] [Europe PMC] [Abstract]

"Purification, biochemical characterization, and cloning of a novel megakaryocyte stimulating factor that has megakaryocyte colony stimulating activity."
Blood 78:279A-279A(1991)

"A comparison of vitronectin and megakaryocyte stimulating factor."
(In) Preissner K.T., Rosenblatt S., Kost C., Wegerhoff J., Mosher D.F. (eds.);Biology of vitronectins and their receptors, pp.45-52, Elsevier Science Publishers B.V., Amsterdam (1993)

"A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage."
Arch. Biochem. Biophys. 311:144-152(1994) [PubMed] [Europe PMC] [Abstract]

"CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome."
Nat. Genet. 23:319-322(1999) [PubMed] [Europe PMC] [Abstract]

"Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes."
Cytogenet. Cell Genet. 90:291-297(2000) [PubMed] [Europe PMC] [Abstract]

"Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts."
J. Rheumatol. 27:594-600(2000) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"The O-glycomap of lubricin, a novel mucin responsible for joint lubrication, identified by site-specific glycopeptide analysis."
Mol. Cell. Proteomics 13:3396-3409(2014) [PubMed] [Europe PMC] [Abstract]