Absent In Melanoma 1 (AIM1)

ST4; CRYBG1; Suppression Of Tumorigenicity 4; Beta-Gamma Crystallin Domain Containing 1

SPN	Q511
HGNC	356
MGI	109544
PubMed	11700328
UniProt	Q9Y4K1
Wiki	AIM1

AIM1 (absent in melanoma-1) is a novel gene whose expression is altered in association with tumor suppression in a model of human melanoma . Chromosome banding analysis of human malignant melanoma documented nonrandom alteration in chromosome 6.

All known members of this superfamily contain 2 or 4 characteristic motifs arranged in 1 or 2 symmetrical domains. AIM1, in contrast, contains 12 beta-gamma motifs, suggesting a 6-domain structure resembling a trimer of beta- or gamma-crystallin subunits. The structure of the AIM1 gene shows remarkable similarity to the beta-crystallin genes, with homologous introns delineating equivalent protein structural units.

Reference

"AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma."
Proc. Natl. Acad. Sci. U.S.A. 94:3229-3234(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the fifth crystallin domain of the non-lens protein, absent in melanoma 1."
Submitted (JUN-2006) to the PDB data bank

"Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1)."
J. Mol. Biol. 381:509-518(2008) [PubMed] [Europe PMC] [Abstract]