Absent In Melanoma 2 (AIM2)

PYHIN4; Interferon-inducible protein AIM2

SPN	Q510
HGNC	357
MGI	2686159
PubMed	22555457
RGD	1307283
UniProt	O14862
Wiki	AIM2

AIM2 plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. AIM2 was expressed as a 39-kD protein following in vitro transcription/translation in rabbit reticulocyte lysate or transfection in a murine epithelial cell line. Cell fractionation showed that AIM2 localized primarily to the cytoplasm of transfected mouse cells.

Chromosome alterations in malignant melanoma most frequently include translocations and deletions on chromosome 1 or 6 . AIM2 encodes a deduced 344-amino acid protein that contains a conserved sequence domain of approximately 200 amino acids shared with interferon-inducible genes as well as a tyrosine kinase phosphorylation site.

Reference

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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2."
Biochem. Biophys. Res. Commun. 326:417-424(2005) [PubMed] [Europe PMC] [Abstract]

"AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model."
Mol. Cancer Ther. 5:1-7(2006) [PubMed] [Europe PMC] [Abstract]

"The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers."
Genes Chromosomes Cancer 46:1080-1089(2007) [PubMed] [Europe PMC] [Abstract]

"An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome."
Nat. Immunol. 10:266-272(2009) [PubMed] [Europe PMC] [Abstract]

"AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA."
Nature 458:509-513(2009) [PubMed] [Europe PMC] [Abstract]

"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC."
Nature 458:514-518(2009) [PubMed] [Europe PMC] [Abstract]

"Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes."
J. Immunol. 185:1186-1195(2010) [PubMed] [Europe PMC] [Abstract]

"IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes."
PLoS ONE 6:E27040-E27040(2011) [PubMed] [Europe PMC] [Abstract]

"Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated AIM2 inflammasomes."
Mol. Cell. Proteomics 11:1230-1244(2012) [PubMed] [Europe PMC] [Abstract]

"Novel role of PKR in inflammasome activation and HMGB1 release."
Nature 488:670-674(2012) [PubMed] [Europe PMC] [Abstract]

"Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor."
Immunity 36:561-571(2012) [PubMed] [Europe PMC] [Abstract]