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Phosphoglycerate Kinase 1 (PGK1)

MIG10; PGKA; PRP 2; Cell migration-inducing gene 10 protein; Primer recognition protein 2

The Phosphoglycerate Kinase 1 is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19.PGK1 is distinguished from testicular PGK2, which maps to chromosome 6p21.
The deduced protein contains 417 amino acid residues. Southern blot analysis of human genomic DNAs showed a complex pattern of hybridizing fragments, 2 of which were non-X in origin. The results were interpreted as reflecting the existence of a small family of dispersed PGK or PGK-like genes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ508Hu01 Recombinant Phosphoglycerate Kinase 1 (PGK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ508Hu01 Monoclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IP.
PAQ508Hu01 Polyclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IF.
Assay Kits CLQ508Hu01 CLIA Kit for Phosphoglycerate Kinase 1 (PGK1) CLIA assay for Antigen Detection
ELQ508Hu01 ELISA Kit for Phosphoglycerate Kinase 1 (PGK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ508Mu01 Recombinant Phosphoglycerate Kinase 1 (PGK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ508Mu01 Monoclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IP.
PAQ508Mu01 Polyclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IF.
Assay Kits CLQ508Mu01 CLIA Kit for Phosphoglycerate Kinase 1 (PGK1) CLIA assay for Antigen Detection
ELQ508Mu01 ELISA Kit for Phosphoglycerate Kinase 1 (PGK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ508Ra01 Recombinant Phosphoglycerate Kinase 1 (PGK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ508Ra01 Monoclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IP.
PAQ508Ra01 Polyclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IF.
Assay Kits CLQ508Ra01 CLIA Kit for Phosphoglycerate Kinase 1 (PGK1) CLIA assay for Antigen Detection
ELQ508Ra01 ELISA Kit for Phosphoglycerate Kinase 1 (PGK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ508Ca01 Recombinant Phosphoglycerate Kinase 1 (PGK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ508Ca01 Monoclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IP.
PAQ508Ca01 Polyclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IF.
Assay Kits CLQ508Ca01 CLIA Kit for Phosphoglycerate Kinase 1 (PGK1) CLIA assay for Antigen Detection
ELQ508Ca01 ELISA Kit for Phosphoglycerate Kinase 1 (PGK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ508Po01 Recombinant Phosphoglycerate Kinase 1 (PGK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ508Po01 Monoclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IP.
PAQ508Po01 Polyclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IF.
Assay Kits CLQ508Po01 CLIA Kit for Phosphoglycerate Kinase 1 (PGK1) CLIA assay for Antigen Detection
ELQ508Po01 ELISA Kit for Phosphoglycerate Kinase 1 (PGK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ508Bo01 Recombinant Phosphoglycerate Kinase 1 (PGK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ508Bo01 Monoclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IP.
PAQ508Bo01 Polyclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IF.
Assay Kits CLQ508Bo01 CLIA Kit for Phosphoglycerate Kinase 1 (PGK1) CLIA assay for Antigen Detection
ELQ508Bo01 ELISA Kit for Phosphoglycerate Kinase 1 (PGK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ508Rb01 Recombinant Phosphoglycerate Kinase 1 (PGK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ508Rb01 Monoclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IP.
PAQ508Rb01 Polyclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IF.
Assay Kits CLQ508Rb01 CLIA Kit for Phosphoglycerate Kinase 1 (PGK1) CLIA assay for Antigen Detection
ELQ508Rb01 ELISA Kit for Phosphoglycerate Kinase 1 (PGK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ508Mo01 Recombinant Phosphoglycerate Kinase 1 (PGK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ508Mo01 Monoclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IP.
PAQ508Mo01 Polyclonal Antibody to Phosphoglycerate Kinase 1 (PGK1) WB; IHC; ICC; IF.
Assay Kits CLQ508Mo01 CLIA Kit for Phosphoglycerate Kinase 1 (PGK1) CLIA assay for Antigen Detection
ELQ508Mo01 ELISA Kit for Phosphoglycerate Kinase 1 (PGK1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Proc. Natl. Acad. Sci. U.S.A. 80:472-476(1983) [PubMed] [Europe PMC] [Abstract]

"Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain."
Proc. Natl. Acad. Sci. U.S.A. 82:6965-6969(1985) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]."
Gene 32:409-417(1984) [PubMed] [Europe PMC] [Abstract]

"Genomic sequencing and methylation analysis by ligation mediated PCR."
Science 246:810-813(1989) [PubMed] [Europe PMC] [Abstract]

"Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence."
J. Biol. Chem. 255:6412-6420(1980) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"Functional identity of a primer recognition protein as phosphoglycerate kinase."
J. Biol. Chem. 265:6540-6543(1990) [PubMed] [Europe PMC] [Abstract]

"Hematologically important mutations: molecular abnormalities of phosphoglycerate kinase."
Blood Cells Mol. Dis. 22:265-267(1996) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The first identification of lysine malonylation substrates and its regulatory enzyme."
Mol. Cell. Proteomics 10:M111.012658.01-M111.012658.12(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase."
Nucleic Acids Res. 36:3620-3629(2008) [PubMed] [Europe PMC] [Abstract]

"Molecular abnormality of a phosphoglycerate kinase variant (PGK-Alabama)."
Blood Cells Mol. Dis. 21:179-181(1995) [PubMed] [Europe PMC] [Abstract]

"Identification of new mutations in two phosphoglycerate kinase (PGK) variants expressing different clinical syndromes: PGK Creteil and PGK Amiens."
Blood 84:898-903(1994) [PubMed] [Europe PMC] [Abstract]

"Retarded and aberrant splicings caused by single exon mutation in a phosphoglycerate kinase variant."
Arch. Biochem. Biophys. 327:35-40(1996) [PubMed] [Europe PMC] [Abstract]

"A phosphoglycerate kinase mutant (PGK Herlev; D285V) in a Danish patient with isolated chronic hemolytic anemia: mechanism of mutation and structure-function relationships."
Hum. Mutat. 12:280-287(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu-->Pro substitution caused by T/A-->C/G transition in exon 3."
Blood 77:1348-1352(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation."
Blood 79:2759-2762(1992) [PubMed] [Europe PMC] [Abstract]

"A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK Munchen) associated with enzyme deficiency."
J. Biol. Chem. 255:6421-6423(1980) [PubMed] [Europe PMC] [Abstract]

"Structure and function of normal and variant human phosphoglycerate kinase."
Hemoglobin 4:601-609(1980) [PubMed] [Europe PMC] [Abstract]

"A single amino acid substitution (157 Gly-->Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria."
Blood 79:1582-1585(1992) [PubMed] [Europe PMC] [Abstract]

"Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia."
Proc. Natl. Acad. Sci. U.S.A. 78:2587-2590(1981) [PubMed] [Europe PMC] [Abstract]

"Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia."
Proc. Natl. Acad. Sci. U.S.A. 77:5461-5465(1980) [PubMed] [Europe PMC] [Abstract]