Pregnancy Zone Protein (PZP)

CPAMD6; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

SPN	Q488
HGNC	9750
MGI	87854
PubMed	1692292
RGD	628643
UniProt	P20742
Wiki	PZP

Pregnancy zone protein (PZP), one of the major pregnancy-associated plasma proteins, was described by Smithies (1959) who used zone-electrophoresis in starch gels. PZP is a prominent constituent of late-pregnancy sera. In healthy, nonpregnant females and in males, PZP is present in trace amounts only: females, 10-30 mg/l; males, less than 10 mg/l. During pregnancy, PZP levels may reach 1000-1400 mg/l just before term. Sottrup-Jensen et al. (1984) showed that PZP closely resembles alpha-2-macroglobulin in structure. Both have a quaternary structure of 2 covalently bound 180-kD subunits which are further noncovalently assembled into a tetramer of 720 kD. Amino acid sequence of the 2 proteins are extensively homologous.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ488Hu01	Recombinant Pregnancy Zone Protein (PZP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ488Hu01	Monoclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IP.
Antibodies	PAQ488Hu01	Polyclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IF.
Assay Kits	CLQ488Hu01	CLIA Kit for Pregnancy Zone Protein (PZP)	CLIA assay for Antigen Detection
Assay Kits	ELQ488Hu01	ELISA Kit for Pregnancy Zone Protein (PZP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ488Mu01	Recombinant Pregnancy Zone Protein (PZP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ488Mu01	Monoclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IP.
Antibodies	PAQ488Mu01	Polyclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IF.
Assay Kits	CLQ488Mu01	CLIA Kit for Pregnancy Zone Protein (PZP)	CLIA assay for Antigen Detection
Assay Kits	ELQ488Mu01	ELISA Kit for Pregnancy Zone Protein (PZP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ488Ra01	Recombinant Pregnancy Zone Protein (PZP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ488Ra01	Monoclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IP.
Antibodies	PAQ488Ra01	Polyclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IF.
Assay Kits	CLQ488Ra01	CLIA Kit for Pregnancy Zone Protein (PZP)	CLIA assay for Antigen Detection
Assay Kits	ELQ488Ra01	ELISA Kit for Pregnancy Zone Protein (PZP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ488Ca01	Recombinant Pregnancy Zone Protein (PZP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ488Ca01	Monoclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IP.
Antibodies	PAQ488Ca01	Polyclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IF.
Assay Kits	CLQ488Ca01	CLIA Kit for Pregnancy Zone Protein (PZP)	CLIA assay for Antigen Detection
Assay Kits	ELQ488Ca01	ELISA Kit for Pregnancy Zone Protein (PZP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ488Po01	Recombinant Pregnancy Zone Protein (PZP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ488Po01	Monoclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IP.
Antibodies	PAQ488Po01	Polyclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IF.
Assay Kits	CLQ488Po01	CLIA Kit for Pregnancy Zone Protein (PZP)	CLIA assay for Antigen Detection
Assay Kits	ELQ488Po01	ELISA Kit for Pregnancy Zone Protein (PZP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ488Bo01	Recombinant Pregnancy Zone Protein (PZP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ488Bo01	Monoclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IP.
Antibodies	PAQ488Bo01	Polyclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IF.
Assay Kits	CLQ488Bo01	CLIA Kit for Pregnancy Zone Protein (PZP)	CLIA assay for Antigen Detection
Assay Kits	ELQ488Bo01	ELISA Kit for Pregnancy Zone Protein (PZP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ488Rb01	Recombinant Pregnancy Zone Protein (PZP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ488Rb01	Monoclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IP.
Antibodies	PAQ488Rb01	Polyclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IF.
Assay Kits	CLQ488Rb01	CLIA Kit for Pregnancy Zone Protein (PZP)	CLIA assay for Antigen Detection
Assay Kits	ELQ488Rb01	ELISA Kit for Pregnancy Zone Protein (PZP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ488Mo01	Recombinant Pregnancy Zone Protein (PZP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ488Mo01	Monoclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IP.
Antibodies	PAQ488Mo01	Polyclonal Antibody to Pregnancy Zone Protein (PZP)	WB; IHC; ICC; IF.
Assay Kits	CLQ488Mo01	CLIA Kit for Pregnancy Zone Protein (PZP)	CLIA assay for Antigen Detection
Assay Kits	ELQ488Mo01	ELISA Kit for Pregnancy Zone Protein (PZP)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Primary structure of pregnancy zone protein. Molecular cloning of a full-length PZP cDNA clone by the polymerase chain reaction."
Biochim. Biophys. Acta 1088:95-103(1991) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Alpha-macroglobulin domain structure studied by specific limited proteolysis."
Arch. Biochem. Biophys. 300:327-334(1993) [PubMed] [Europe PMC] [Abstract]

"A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin."
FEBS Lett. 262:349-352(1990) [PubMed] [Europe PMC] [Abstract]

"The alpha-macroglobulin bait region. Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins."
J. Biol. Chem. 264:15781-15789(1989) [PubMed] [Europe PMC] [Abstract]

"Characterization of human pregnancy zone protein. Comparison with human alpha 2-macroglobulin."
J. Biol. Chem. 260:15723-15735(1985) [PubMed] [Europe PMC] [Abstract]

"A cluster of alpha 2-macroglobulin-related genes (alpha 2 M) on human chromosome 12p: cloning of the pregnancy-zone protein gene and an alpha 2M pseudogene."
Gene 81:325-334(1989) [PubMed] [Europe PMC] [Abstract]

"Pregnancy zone protein, a proteinase-binding macroglobulin. Interactions with proteinases and methylamine."
Biochemistry 28:9324-9331(1989) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]