Hydroxyacid Oxidase 1 (HAO1)
GOX; Glycolate Oxidase
HAO1 is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.The full-length cDNA of Hao1 encodes a deduced 370-amino acid protein with a predicted molecular mass of 4.1 kD. The Hao1 protein contains an IRE-like sequence in the 3-prime untranslated region, with one mismatch in the predicted upper stem structure.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ447Hu01 | Recombinant Hydroxyacid Oxidase 1 (HAO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ447Hu01 | Monoclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IP. |
| PAQ447Hu01 | Polyclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ447Hu01 | CLIA Kit for Hydroxyacid Oxidase 1 (HAO1) | CLIA assay for Antigen Detection |
| ELQ447Hu01 | ELISA Kit for Hydroxyacid Oxidase 1 (HAO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ447Mu01 | Recombinant Hydroxyacid Oxidase 1 (HAO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ447Mu01 | Monoclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IP. |
| PAQ447Mu01 | Polyclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ447Mu01 | CLIA Kit for Hydroxyacid Oxidase 1 (HAO1) | CLIA assay for Antigen Detection |
| ELQ447Mu01 | ELISA Kit for Hydroxyacid Oxidase 1 (HAO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ447Ra01 | Recombinant Hydroxyacid Oxidase 1 (HAO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ447Ra01 | Monoclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IP. |
| PAQ447Ra01 | Polyclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ447Ra01 | CLIA Kit for Hydroxyacid Oxidase 1 (HAO1) | CLIA assay for Antigen Detection |
| ELQ447Ra01 | ELISA Kit for Hydroxyacid Oxidase 1 (HAO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ447Ca01 | Recombinant Hydroxyacid Oxidase 1 (HAO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ447Ca01 | Monoclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IP. |
| PAQ447Ca01 | Polyclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ447Ca01 | CLIA Kit for Hydroxyacid Oxidase 1 (HAO1) | CLIA assay for Antigen Detection |
| ELQ447Ca01 | ELISA Kit for Hydroxyacid Oxidase 1 (HAO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ447Po01 | Recombinant Hydroxyacid Oxidase 1 (HAO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ447Po01 | Monoclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IP. |
| PAQ447Po01 | Polyclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ447Po01 | CLIA Kit for Hydroxyacid Oxidase 1 (HAO1) | CLIA assay for Antigen Detection |
| ELQ447Po01 | ELISA Kit for Hydroxyacid Oxidase 1 (HAO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ447Bo01 | Recombinant Hydroxyacid Oxidase 1 (HAO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ447Bo01 | Monoclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IP. |
| PAQ447Bo01 | Polyclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ447Bo01 | CLIA Kit for Hydroxyacid Oxidase 1 (HAO1) | CLIA assay for Antigen Detection |
| ELQ447Bo01 | ELISA Kit for Hydroxyacid Oxidase 1 (HAO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ447Rb01 | Recombinant Hydroxyacid Oxidase 1 (HAO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ447Rb01 | Monoclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IP. |
| PAQ447Rb01 | Polyclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ447Rb01 | CLIA Kit for Hydroxyacid Oxidase 1 (HAO1) | CLIA assay for Antigen Detection |
| ELQ447Rb01 | ELISA Kit for Hydroxyacid Oxidase 1 (HAO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ447Mo01 | Recombinant Hydroxyacid Oxidase 1 (HAO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ447Mo01 | Monoclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IP. |
| PAQ447Mo01 | Polyclonal Antibody to Hydroxyacid Oxidase 1 (HAO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ447Mo01 | CLIA Kit for Hydroxyacid Oxidase 1 (HAO1) | CLIA assay for Antigen Detection |
| ELQ447Mo01 | ELISA Kit for Hydroxyacid Oxidase 1 (HAO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and expression of a cDNA for human glycolate oxidase."
Biochim. Biophys. Acta 1493:246-248(2000) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases."
J. Biol. Chem. 275:12590-12597(2000) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design."
Biochemistry 47:2439-2449(2008) [PubMed] [Europe PMC] [Abstract]
"Structure of human glycolate oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole."
Acta Crystallogr. F 65:1246-1253(2009) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human hydroxyacid oxidase 1."
Submitted (FEB-2009) to the PDB data bank