ATPase, H+ Transporting, Mitochondrial F1 Complex Beta Polypeptide (ATP5b)

ATPMB; ATPSB

SPN	Q424
HGNC	830
MGI	107801
PubMed	22261716
RGD	621368
UniProt	P06576
Wiki	ATP5B

ATP5b encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel.

The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.

Reference

"The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression."
Genomics 5:829-843(1989) [PubMed] [Europe PMC] [Abstract]

"Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit."
J. Biol. Chem. 263:11257-11262(1988) [PubMed] [Europe PMC] [Abstract]

"Human F1-ATPase: molecular cloning of cDNA for the beta subunit."
J. Biochem. 99:135-141(1986) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations."
Curr. Genet. 12:81-90(1987) [PubMed] [Europe PMC] [Abstract]

"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]