Desmocollin 1 (DSC1)

CDHF1; DG2/DG3; Cadherin family member 1; Desmosomal glycoprotein 2/3

SPN	Q377
HGNC	3035
MGI	109173
PubMed	9242496
RGD	1310768
UniProt	Q08554
Wiki	DSC1

Desmocollin-1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.Strongly expressed in epidermis, less in lymph node and tongue.The glycoproteins of 115 kD and 100 kD were named desmocollins to denote that they are involved in the adhesive function of the desmosomes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	Q377Hu01	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	MQ377Hu21	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	PQ377Hu01	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	KEQ377Hu	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	Q377Mu01	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	PQ377Mu01	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	KEQ377Mu	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Desmocollin 1 (DSC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Desmocollin 1 (DSC1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Desmocollin 1 (DSC1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Desmocollin 1 (DSC1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Desmocollin 1 (DSC1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Desmocollin 1 (DSC1)	CLIA assay for Antigen Detection

Reference

"Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia."
Int. J. Dev. Biol. 37:101-110(1993) [PubMed] [Europe PMC] [Abstract]

"Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18."
Genomics 18:185-194(1993) [PubMed] [Europe PMC] [Abstract]

"Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3."
Biochem. Biophys. Res. Commun. 276:454-460(2000) [PubMed] [Europe PMC] [Abstract]

"Keratinization is associated with the expression of a new protein related to the desmosomal cadherins DGII/III."
FEBS Lett. 286:9-12(1991) [PubMed] [Europe PMC] [Abstract]

"Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]

"Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes."
J. Biol. Chem. 284:31776-31788(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]