Call Now

Desmocollin 2 (DSC2)

ARVD11; CDHF2; DG2; DGII/III; Cadherin family member 2; Desmosomal glycoprotein III

Desmocollin-2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.Exon 16 is alternatively spliced, giving rise to the a and b forms of the protein. A remarkable degree of conservation of intron position with other cadherins was observed.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ376Hu01 Recombinant Desmocollin 2 (DSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ376Hu01 Monoclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
PAQ376Hu01 Polyclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IF.
Assay Kits CLQ376Hu01 CLIA Kit for Desmocollin 2 (DSC2) CLIA assay for Antigen Detection
ELQ376Hu01 ELISA Kit for Desmocollin 2 (DSC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ376Mu01 Recombinant Desmocollin 2 (DSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ376Mu01 Monoclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
PAQ376Mu01 Polyclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IF.
Assay Kits CLQ376Mu01 CLIA Kit for Desmocollin 2 (DSC2) CLIA assay for Antigen Detection
ELQ376Mu01 ELISA Kit for Desmocollin 2 (DSC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ376Ra01 Recombinant Desmocollin 2 (DSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ376Ra01 Monoclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
PAQ376Ra01 Polyclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IF.
Assay Kits CLQ376Ra01 CLIA Kit for Desmocollin 2 (DSC2) CLIA assay for Antigen Detection
ELQ376Ra01 ELISA Kit for Desmocollin 2 (DSC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ376Ca01 Recombinant Desmocollin 2 (DSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ376Ca01 Monoclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
PAQ376Ca01 Polyclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IF.
Assay Kits CLQ376Ca01 CLIA Kit for Desmocollin 2 (DSC2) CLIA assay for Antigen Detection
ELQ376Ca01 ELISA Kit for Desmocollin 2 (DSC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ376Po01 Recombinant Desmocollin 2 (DSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ376Po01 Monoclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
PAQ376Po01 Polyclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IF.
Assay Kits CLQ376Po01 CLIA Kit for Desmocollin 2 (DSC2) CLIA assay for Antigen Detection
ELQ376Po01 ELISA Kit for Desmocollin 2 (DSC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ376Bo01 Recombinant Desmocollin 2 (DSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ376Bo01 Monoclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
PAQ376Bo01 Polyclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IF.
Assay Kits CLQ376Bo01 CLIA Kit for Desmocollin 2 (DSC2) CLIA assay for Antigen Detection
ELQ376Bo01 ELISA Kit for Desmocollin 2 (DSC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ376Rb01 Recombinant Desmocollin 2 (DSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ376Rb01 Monoclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
PAQ376Rb01 Polyclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IF.
Assay Kits CLQ376Rb01 CLIA Kit for Desmocollin 2 (DSC2) CLIA assay for Antigen Detection
ELQ376Rb01 ELISA Kit for Desmocollin 2 (DSC2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ376Mo01 Recombinant Desmocollin 2 (DSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ376Mo01 Monoclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
PAQ376Mo01 Polyclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IF.
Assay Kits CLQ376Mo01 CLIA Kit for Desmocollin 2 (DSC2) CLIA assay for Antigen Detection
ELQ376Mo01 ELISA Kit for Desmocollin 2 (DSC2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing."
J. Biol. Chem. 266:10438-10445(1991) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

"Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2."
Am. J. Hum. Genet. 79:978-984(2006) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

"Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."
Cardiovasc. Res. 90:77-87(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy."
Mol. Genet. Metab. 95:74-80(2008) [PubMed] [Europe PMC] [Abstract]

"Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."
Circ. Cardiovasc. Genet. 2:428-435(2009) [PubMed] [Europe PMC] [Abstract]

"Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."
Clin. Genet. 77:37-48(2010) [PubMed] [Europe PMC] [Abstract]