Dipeptidyl Peptidase 9 (DPP9)

DPRP2; DPLP9; Dipeptidylpeptidase 9; Dipeptidyl peptidase IV-related protein 2; Dipeptidyl peptidase-like protein 9; Dipeptidyl peptidase IX

SPN	Q368
HGNC	18648
MGI	2443967
PubMed	19667070
RGD	1588575
UniProt	Q86TI2
Wiki	DPP9

Dipeptidyl peptidase 9 is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins.

Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized.

Reference

"Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV."
Gene 299:185-193(2002) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases."
Biochem. J. 373:179-189(2003) [PubMed] [Europe PMC] [Abstract]

"Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity."
Biochim. Biophys. Acta 1679:18-28(2004) [PubMed] [Europe PMC] [Abstract]

"Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV."
Biochem. J. 396:391-399(2006) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus."
Cell. Mol. Life Sci. 71:3611-3626(2014) [PubMed] [Europe PMC] [Abstract]