Dipeptidyl Peptidase 6 (DPP6)

DPPX; Dipeptidylpeptidase 6; Dipeptidyl aminopeptidase-like protein 6; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase IV-like protein

SPN	Q365
HGNC	3010
MGI	94921
PubMed	19285295
RGD	68402
UniProt	P42658
Wiki	DPP6

Dipeptidyl aminopeptidase-like protein 6 is a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.This trend was most pronounced for the subset of genes implicated in nervous system development. Moreover, within primates, the acceleration of protein evolution was most prominent in the lineage leading from ancestral primates to humans.

Reference

"Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7."
Hum. Mol. Genet. 2:1037-1039(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)."
Biophys. J. 87:2380-2396(2004) [PubMed] [Europe PMC] [Abstract]

"I SA channel complexes include four subunits each of DPP6 and Kv4.2."
J. Biol. Chem. 283:15072-15077(2008) [PubMed] [Europe PMC] [Abstract]

"Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis."
Nat. Genet. 40:29-31(2008) [PubMed] [Europe PMC] [Abstract]

"Genetics. The elusive ALS genes."
Science 319:20-20(2008) [PubMed] [Europe PMC] [Abstract]

"Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation."
Am. J. Hum. Genet. 84:468-476(2009) [PubMed] [Europe PMC] [Abstract]

"Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits."
Biochemistry 48:5721-5730(2009) [PubMed] [Europe PMC] [Abstract]

"Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family."
J. Mol. Biol. 343:1055-1065(2004) [PubMed] [Europe PMC] [Abstract]