Histidine Decarboxylase (HDC)

SPN	Q333
HGNC	4855
MGI	96062
PubMed	21873469
RGD	2790
UniProt	P19113
Wiki	HDC

The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC). This homodimeric enzyme is a pyridoxal phosphate (PLP)-dependent decarboxylase and is highly specific for its histidine substrate. A high degree of homology was found among the HDCs and the dopa decarboxylases (DDC) of rat, mouse, and human.The gene contains 12 exons spanning approximately 24 kb. Genomic DNA blot analysis suggested that HDC is encoded by a single copy gene. Structural analysis showed that the observed heterogeneity of the HDC mRNA is caused by alternative splicing.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ333Hu01	Recombinant Histidine Decarboxylase (HDC)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ333Hu01	Monoclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IP.
Antibodies	PAQ333Hu01	Polyclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IF.
Assay Kits	CLQ333Hu01	CLIA Kit for Histidine Decarboxylase (HDC)	CLIA assay for Antigen Detection
Assay Kits	ELQ333Hu01	ELISA Kit for Histidine Decarboxylase (HDC)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ333Mu01	Recombinant Histidine Decarboxylase (HDC)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ333Mu01	Monoclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IP.
Antibodies	PAQ333Mu01	Polyclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IF.
Assay Kits	CLQ333Mu01	CLIA Kit for Histidine Decarboxylase (HDC)	CLIA assay for Antigen Detection
Assay Kits	ELQ333Mu01	ELISA Kit for Histidine Decarboxylase (HDC)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ333Ra01	Recombinant Histidine Decarboxylase (HDC)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ333Ra01	Monoclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IP.
Antibodies	PAQ333Ra01	Polyclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IF.
Assay Kits	CLQ333Ra01	CLIA Kit for Histidine Decarboxylase (HDC)	CLIA assay for Antigen Detection
Assay Kits	ELQ333Ra01	ELISA Kit for Histidine Decarboxylase (HDC)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ333Ca01	Recombinant Histidine Decarboxylase (HDC)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ333Ca01	Monoclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IP.
Antibodies	PAQ333Ca01	Polyclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IF.
Assay Kits	CLQ333Ca01	CLIA Kit for Histidine Decarboxylase (HDC)	CLIA assay for Antigen Detection
Assay Kits	ELQ333Ca01	ELISA Kit for Histidine Decarboxylase (HDC)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ333Po01	Recombinant Histidine Decarboxylase (HDC)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ333Po01	Monoclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IP.
Antibodies	PAQ333Po01	Polyclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IF.
Assay Kits	CLQ333Po01	CLIA Kit for Histidine Decarboxylase (HDC)	CLIA assay for Antigen Detection
Assay Kits	ELQ333Po01	ELISA Kit for Histidine Decarboxylase (HDC)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ333Bo01	Recombinant Histidine Decarboxylase (HDC)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ333Bo01	Monoclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IP.
Antibodies	PAQ333Bo01	Polyclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IF.
Assay Kits	CLQ333Bo01	CLIA Kit for Histidine Decarboxylase (HDC)	CLIA assay for Antigen Detection
Assay Kits	ELQ333Bo01	ELISA Kit for Histidine Decarboxylase (HDC)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ333Rb01	Recombinant Histidine Decarboxylase (HDC)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ333Rb01	Monoclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IP.
Antibodies	PAQ333Rb01	Polyclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IF.
Assay Kits	CLQ333Rb01	CLIA Kit for Histidine Decarboxylase (HDC)	CLIA assay for Antigen Detection
Assay Kits	ELQ333Rb01	ELISA Kit for Histidine Decarboxylase (HDC)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ333Mo01	Recombinant Histidine Decarboxylase (HDC)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ333Mo01	Monoclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IP.
Antibodies	PAQ333Mo01	Polyclonal Antibody to Histidine Decarboxylase (HDC)	WB; IHC; ICC; IF.
Assay Kits	CLQ333Mo01	CLIA Kit for Histidine Decarboxylase (HDC)	CLIA assay for Antigen Detection
Assay Kits	ELQ333Mo01	ELISA Kit for Histidine Decarboxylase (HDC)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Nucleotide sequence of the cDNA encoding L-histidine decarboxylase derived from human basophilic leukemia cell line, KU-812-F."
Nucleic Acids Res. 18:5891-5891(1990) [PubMed] [Europe PMC] [Abstract]

"Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15."
DNA Seq. 1:395-400(1991) [PubMed] [Europe PMC] [Abstract]

"Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells."
Eur. J. Biochem. 209:533-539(1992) [PubMed] [Europe PMC] [Abstract]

"Structure of the L-histidine decarboxylase gene."
J. Biol. Chem. 269:1554-1559(1994) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase."
J. Biol. Chem. 287:29175-29183(2012) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]