Growth Arrest Specific Protein 6 (GAS6)

AXLLG; AXSF; AXL Stimulatory Factor; AXL receptor tyrosine kinase ligand

SPN	Q326
HGNC	4168
MGI	95660
PubMed	17897008
RGD	61913
UniProt	Q14393
Wiki	GAS6

Growth arrest-specific 6 is similar to the Protein S with the same domain organization and 43% amino acid identity. GAS6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation. The gene is expressed as an abundant 2.6-kb mRNA in starved cells but decreases significantly upon stimulation of cells with serum or fibroblast growth factor. A human homolog was isolated from HeLa cells and was predicted to encode a 678-amino acid protein with 81% identity to the mouse protein and 44% identity to human protein S, a vitamin K-dependent negative coregulator in the blood coagulation pathway. Regions of greatest similarity between Gas6 and protein S occur in a gamma carboxylated glutamic acid-rich domain and in 4 EGF-like domains.

Reference

"The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade."
Mol. Cell. Biol. 13:4976-4985(1993) [PubMed] [Europe PMC] [Abstract]

"Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke."
Hum. Mutat. 23:506-512(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6."
Nature 373:623-626(1995) [PubMed] [Europe PMC] [Abstract]

"The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases."
Cell 80:661-670(1995) [PubMed] [Europe PMC] [Abstract]

"Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6."
FEBS Lett. 415:56-58(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases."
J. Biol. Chem. 271:30022-30027(1996) [PubMed] [Europe PMC] [Abstract]

"The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation."
FEBS Lett. 415:59-63(1997) [PubMed] [Europe PMC] [Abstract]

"Acidification prevents endothelial cell apoptosis by Axl activation."
Circ. Res. 91:E4-12(2002) [PubMed] [Europe PMC] [Abstract]

"The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development."
Blood 113:2470-2477(2009) [PubMed] [Europe PMC] [Abstract]

"Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl."
J. Biol. Chem. 271:9785-9789(1996) [PubMed] [Europe PMC] [Abstract]

"Structural basis for Gas6-Axl signalling."
EMBO J. 25:80-87(2006) [PubMed] [Europe PMC] [Abstract]