Farnesyltransferase Alpha (FNTa)
FPTA; PTAR2; PGGT1A; Protein Prenyltransferase Alpha Subunit Repeat Containing 2; CAAX farnesyltransferase subunit alpha; Ras proteins prenyltransferase subunit alpha
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | Q317Hu01 | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | MQ317Hu21 | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
PQ317Hu01 | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | KEQ317Hu | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Farnesyltransferase Alpha (FNTa) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Farnesyltransferase Alpha (FNTa) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Farnesyltransferase Alpha (FNTa) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Farnesyltransferase Alpha (FNTa) | CLIA assay for Antigen Detection |
Reference
"cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences."
Genomics 18:105-112(1993) [PubMed] [Europe PMC] [Abstract]
"Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role."
J. Biol. Chem. 268:1383-1390(1993) [PubMed] [Europe PMC] [Abstract]
"Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases."
Biochemistry 32:5167-5176(1993) [PubMed] [Europe PMC] [Abstract]
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
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"A quantitative atlas of mitotic phosphorylation."
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"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
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BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics."
Proc. Natl. Acad. Sci. U.S.A. 98:12948-12953(2001) [PubMed] [Europe PMC] [Abstract]
"3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency."
J. Med. Chem. 45:2388-2409(2002) [PubMed] [Europe PMC] [Abstract]
"Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents."
J. Med. Chem. 46:2973-2984(2003) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity."
Biochemistry 43:6877-6884(2004) [PubMed] [Europe PMC] [Abstract]
"Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity."
J. Mol. Biol. 343:417-433(2004) [PubMed] [Europe PMC] [Abstract]
"Conversion of protein farnesyltransferase to a geranylgeranyltransferase."
Biochemistry 45:9746-9755(2006) [PubMed] [Europe PMC] [Abstract]
"Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase."
Chem. Biol. 16:181-192(2009) [PubMed] [Europe PMC] [Abstract]