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Farnesyltransferase Alpha (FNTa)

FPTA; PTAR2; PGGT1A; Protein Prenyltransferase Alpha Subunit Repeat Containing 2; CAAX farnesyltransferase subunit alpha; Ras proteins prenyltransferase subunit alpha

CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits.
FNTa encodes the alpha subunit of these transferases. The best characterized of the prenyltransferases, CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the remarkable property of farnesylating peptides as short as 4 residues in length that conform to the CAAX consensus sequence.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins Q317Hu01 Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies MQ317Hu21 Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
PQ317Hu01 Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits KEQ317Hu ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Farnesyltransferase Alpha (FNTa) Bioactivity
Antibodies NONE Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Farnesyltransferase Alpha (FNTa) CLIA assay for Antigen Detection

Reference

"cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences."
Genomics 18:105-112(1993) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role."
J. Biol. Chem. 268:1383-1390(1993) [PubMed] [Europe PMC] [Abstract]

"Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases."
Biochemistry 32:5167-5176(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics."
Proc. Natl. Acad. Sci. U.S.A. 98:12948-12953(2001) [PubMed] [Europe PMC] [Abstract]

"3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency."
J. Med. Chem. 45:2388-2409(2002) [PubMed] [Europe PMC] [Abstract]

"Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents."
J. Med. Chem. 46:2973-2984(2003) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity."
Biochemistry 43:6877-6884(2004) [PubMed] [Europe PMC] [Abstract]

"Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity."
J. Mol. Biol. 343:417-433(2004) [PubMed] [Europe PMC] [Abstract]

"Conversion of protein farnesyltransferase to a geranylgeranyltransferase."
Biochemistry 45:9746-9755(2006) [PubMed] [Europe PMC] [Abstract]

"Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase."
Chem. Biol. 16:181-192(2009) [PubMed] [Europe PMC] [Abstract]