Deleted In Liver Cancer 1 (DLC1)

HP; ARHGAP7; STARD12; p122-RhoGAP; StAR-Related Lipid Transfer(START)Domain Containing 12; Rho GTPase-activating protein 7

SPN	Q303
HGNC	2897
MGI	1354949
PubMed	23783552
RGD	68416
UniProt	Q96QB1
Wiki	DLC1

Deleted in Liver Cancer 1 is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p22-p21.3, a region frequently deleted in solid tumors. It is suggested that this gene is a candidate tumor suppressor gene for human liver cancer, as well as for prostate, lung, colorectal, and breast cancers.DLC1 is frequently inactivated in human hepatocellular carcinoma, as well as some nasopharyngeal, lung, breast, prostate, kidney, colon, uterine, ovarian, and gastric cancers.

The DLC1 protein contains four major functional domains: an N-terminal sterile α motif (SAM), a serine-rich (SR) region, a Rho-GAP domain, and a C-terminal steroidogenic acute regulatory protein related lipid-transfer (START) domain. DLC1 is localized to focal adhesions located at the periphery of cells.

Reference

"Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP."
Cancer Res. 58:2196-2199(1998) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors."
Oncogene 30:1923-1935(2011) [PubMed] [Europe PMC] [Abstract]

"Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration."
J. Biol. Chem. 283:32762-32770(2008) [PubMed] [Europe PMC] [Abstract]

"Focal adhesion-localization of START-GAP1/DLC1 is essential for cell motility and morphology."
Genes Cells 14:227-241(2009) [PubMed] [Europe PMC] [Abstract]

"DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain."
Mol. Biol. Cell 20:4400-4411(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the SAM-domain of rho-GTPase-activating protein 7."
Submitted (APR-2007) to the PDB data bank

"Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level."
Biochemistry 48:4040-4049(2009) [PubMed] [Europe PMC] [Abstract]

"The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration."
J. Cell Sci. 122:414-424(2009) [PubMed] [Europe PMC] [Abstract]

"Sequence variants of DLC1 in colorectal and ovarian tumours."
Hum. Mutat. 15:156-165(2000) [PubMed] [Europe PMC] [Abstract]