Lipin 1 (LPIN1)
Phosphatidate phosphatase LPIN1
Lipin-1 has phosphatidate phosphatase activity.This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism.
Database analysis identified the human LPIN1 gene, as well as the human and mouse LPIN2 and LPIN3 genes. Consistent with the observed reduction of adipose tissue mass in fld mice, wildtype Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of 3T3-L1 preadipocytes. The results indicated that lipin is required for normal adipose tissue development, and provided a candidate gene for human lipodystrophy.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEQ302Hu | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | Q302Mu01 | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| PQ302Mu01 | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEQ302Mu | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | Q302Ra01 | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | MQ302Ra21 | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| PQ302Ra01 | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEQ302Ra | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Lipin 1 (LPIN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Lipin 1 (LPIN1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Lipin 1 (LPIN1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Lipin 1 (LPIN1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Lipin 1 (LPIN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Lipin 1 (LPIN1) | CLIA assay for Antigen Detection |
Reference
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"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns."
J. Biol. Chem. 282:3450-3457(2007) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms."
J. Biol. Chem. 285:14628-14638(2010) [PubMed] [Europe PMC] [Abstract]
"Identification of single-nucleotide polymorphisms in the human LPIN1 gene."
J. Hum. Genet. 47:370-372(2002) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
"Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood."
Am. J. Hum. Genet. 83:489-494(2008) [PubMed] [Europe PMC] [Abstract]
Erratum
Am. J. Hum. Genet. 84:95-95(2008)
"Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway."
J. Biol. Chem. 287:3123-3137(2012) [PubMed] [Europe PMC] [Abstract]