Proteolipid Protein 2, Colonic Epithelium Enriched (PLP2)

A4; A4-LSB; A4 Differentiation-Dependent Protein; Intestinal membrane A4 protein

SPN	Q292
HGNC	9087
MGI	1298382
PubMed	15474493
RGD	1587363
UniProt	Q04941
Wiki	PLP2

PLP2 encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5. Oliva et al. (1993) cloned a cDNA encoding the A4 differentiation-dependent protein from a human colon cell line. Fisher et al. (1997) identified the promoter and complete coding sequence of the A4 gene, which is organized into 5 exons spanning approximately 3.5 kb of DNA. The product of this gene is an integral membrane protein, containing 4 putative transmembrane domains that may play a role in cell differentiation in the intestinal epithelium.

Reference

"Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18."
Arch. Biochem. Biophys. 302:183-192(1993) [PubMed] [Europe PMC] [Abstract]

"Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp."
Genomics 45:340-347(1997) [PubMed] [Europe PMC] [Abstract]

"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes."
Genome Res. 16:55-65(2006) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]