Chymase 1,Mast Cell(CMA1) is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides.
In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases.
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Chymase 1, Mast Cell (CMA1)
Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Chymase 1, Mast Cell (CMA1)
Bioactivity
Antibodies
NONE
Monoclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1)
Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Chymase 1, Mast Cell (CMA1)
Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Chymase 1, Mast Cell (CMA1)
CLIA assay for Antigen Detection
Reference
"Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase." J. Biol. Chem. 266:12956-12963(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning of the gene and cDNA for human heart chymase." J. Biol. Chem. 266:17173-17179(1991) [PubMed] [Europe PMC] [Abstract]
"Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions." J. Immunol. 152:4062-4069(1994) [PubMed] [Europe PMC] [Abstract]
"The 2.2-A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity." J. Mol. Biol. 286:163-173(1999) [PubMed] [Europe PMC] [Abstract]