Call Now

Chymase 1, Mast Cell (CMA1)

CYH; CYM; Alpha-chymase; Mast cell protease I

Chymase 1,Mast Cell(CMA1) is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides.
In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins Q290Hu01 Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies MQ290Hu21 Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
PQ290Hu01 Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits KEQ290Hu ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins Q290Mu01 Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
PQ290Mu01 Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
LQ290Mu71 Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
LQ290Mu81 FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits KEQ290Mu ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins Q290Ra01 Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies MQ290Ra21 Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
PQ290Ra01 Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits KEQ290Ra ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Chymase 1, Mast Cell (CMA1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Chymase 1, Mast Cell (CMA1) Bioactivity
Antibodies NONE Monoclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Chymase 1, Mast Cell (CMA1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Chymase 1, Mast Cell (CMA1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Chymase 1, Mast Cell (CMA1) CLIA assay for Antigen Detection

Reference

"Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase."
J. Biol. Chem. 266:12956-12963(1991) [PubMed] [Europe PMC] [Abstract]

"Cloning of the gene and cDNA for human heart chymase."
J. Biol. Chem. 266:17173-17179(1991) [PubMed] [Europe PMC] [Abstract]

"Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions."
J. Immunol. 152:4062-4069(1994) [PubMed] [Europe PMC] [Abstract]

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and molecular cloning of chymase from human tonsils."
FEBS Lett. 323:119-122(1993) [PubMed] [Europe PMC] [Abstract]

"Angiotensin II-forming heart chymase is a mast-cell-specific enzyme."
Biochem. J. 276:567-568(1991) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A."
Biochemistry 36:14318-14324(1997) [PubMed] [Europe PMC] [Abstract]

"The 2.2-A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity."
J. Mol. Biol. 286:163-173(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Mol. Biol. 286:817-817(1999) [PubMed] [Europe PMC] [Abstract]