Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)

AYTL3; AGPAT7; LPAAT; LPEAT2; Lysophosphatidylethanolamine Acyltransferase 2; Acyltransferase Like 3; 1-Acylglycerol-3-Phosphate O-Acyltransferase 7; Plasmalogen synthase

SPN	Q273
HGNC	30059
MGI	2138993
PubMed	23815430
RGD	1311177
UniProt	Q643R3

Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction.The deduced 524-amino acid protein has a calculated molecular mass of 57.2 kD. It has a phosphate acyltransferase domain that shares 15 to 29% amino acid identity with the acyltransferase domains of other AGPATS and contains all the residues essential for acyltransferase activity. AGPAT7 expression in uterus, thymus, pancreas, skeletal muscle, bladder, stomach, lung, and testis. Fluorescence-tagged AGPAT7 showed a perinuclear and punctate distribution in transfected HeLa cells and colocalized with an endoplasmic reticulum marker.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ273Hu01	Recombinant Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ273Hu01	Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IP.
Antibodies	PAQ273Hu01	Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IF.
Assay Kits	CLQ273Hu01	CLIA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	CLIA assay for Antigen Detection
Assay Kits	ELQ273Hu01	ELISA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ273Mu01	Recombinant Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ273Mu01	Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IP.
Antibodies	PAQ273Mu01	Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IF.
Assay Kits	CLQ273Mu01	CLIA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	CLIA assay for Antigen Detection
Assay Kits	ELQ273Mu01	ELISA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ273Ra01	Recombinant Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ273Ra01	Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IP.
Antibodies	PAQ273Ra01	Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IF.
Assay Kits	CLQ273Ra01	CLIA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	CLIA assay for Antigen Detection
Assay Kits	ELQ273Ra01	ELISA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ273Ca01	Recombinant Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ273Ca01	Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IP.
Antibodies	PAQ273Ca01	Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IF.
Assay Kits	CLQ273Ca01	CLIA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	CLIA assay for Antigen Detection
Assay Kits	ELQ273Ca01	ELISA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ273Po01	Recombinant Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ273Po01	Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IP.
Antibodies	PAQ273Po01	Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IF.
Assay Kits	CLQ273Po01	CLIA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	CLIA assay for Antigen Detection
Assay Kits	ELQ273Po01	ELISA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ273Bo01	Recombinant Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ273Bo01	Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IP.
Antibodies	PAQ273Bo01	Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IF.
Assay Kits	CLQ273Bo01	CLIA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	CLIA assay for Antigen Detection
Assay Kits	ELQ273Bo01	ELISA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ273Rb01	Recombinant Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ273Rb01	Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IP.
Antibodies	PAQ273Rb01	Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IF.
Assay Kits	CLQ273Rb01	CLIA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	CLIA assay for Antigen Detection
Assay Kits	ELQ273Rb01	ELISA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ273Mo01	Recombinant Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ273Mo01	Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IP.
Antibodies	PAQ273Mo01	Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	WB; IHC; ICC; IF.
Assay Kits	CLQ273Mo01	CLIA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	CLIA assay for Antigen Detection
Assay Kits	ELQ273Mo01	ELISA Kit for Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7."
DNA Seq. 16:386-390(2005) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2."
J. Biol. Chem. 283:19049-19057(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]