Yes Associated Protein 1 (YAP1)

YAP; YAP2; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; Yes-associated protein YAP65 homolog

SPN	Q257
HGNC	16262
MGI	103262
PubMed	21376238
UniProt	P46937
Wiki	YAP1

YAP1 contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.

The human and mouse cDNAs encode deduced 493- and 531-amino acid proteins, respectively, with significant sequence similarity to the chicken protein. All 3 contain a putative protein module of 38 amino acids that is found in various structural, regulatory, and signaling molecules in yeast, nematode, and mammals and may be involved in protein-protein interaction. The mouse protein contains an imperfect repeat of the module. Because one of the prominent features of the sequence motif is 2 tryptophans, it has been designated the WW domain .

Reference

"Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain."
J. Biol. Chem. 270:14733-14741(1995) [PubMed] [Europe PMC] [Abstract]

"WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus."
J. Biol. Chem. 278:33334-33341(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene."
Gene 509:215-222(2012) [PubMed] [Europe PMC] [Abstract]

"Characterization of the WW domain of human Yes-associated protein and its polyproline containing ligands."
J. Biol. Chem. 272:17070-17077(1997) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73."
J. Cell Biol. 172:589-604(2006) [PubMed] [Europe PMC] [Abstract]

"Regulation of p73 by Hck through kinase-dependent and independent mechanisms."
BMC Mol. Biol. 8:45-45(2007) [PubMed] [Europe PMC] [Abstract]

"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control."
Genes Dev. 21:2747-2761(2007) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"TEAD mediates YAP-dependent gene induction and growth control."
Genes Dev. 22:1962-1971(2008) [PubMed] [Europe PMC] [Abstract]

"Tumor suppressor LATS1 is a negative regulator of oncogene YAP."
J. Biol. Chem. 283:5496-5509(2008) [PubMed] [Europe PMC] [Abstract]

"Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage."
Mol. Cell 29:350-361(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis."
Cell Death Dis. 1:E29-E29(2010) [PubMed] [Europe PMC] [Abstract]

"A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)."
Genes Dev. 24:72-85(2010) [PubMed] [Europe PMC] [Abstract]

"Structural basis of YAP recognition by TEAD4 in the hippo pathway."
Genes Dev. 24:290-300(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"PTPN14 interacts with and negatively regulates the oncogenic function of YAP."
Oncogene 32:1266-1273(2013) [PubMed] [Europe PMC] [Abstract]

"Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects."
Am. J. Hum. Genet. 94:295-302(2014) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope."
J. Mol. Biol. 314:1147-1156(2001) [PubMed] [Europe PMC] [Abstract]

"Using flexible loop mimetics to extend phi-value analysis to secondary structure interactions."
Proc. Natl. Acad. Sci. U.S.A. 98:13008-13013(2001) [PubMed] [Europe PMC] [Abstract]

"Structural insights into the YAP and TEAD complex."
Genes Dev. 24:235-240(2010) [PubMed] [Europe PMC] [Abstract]