Organic Solute Carrier Partner 1 (OSCP1)

NOR1; C1orf102; Oxidored Nitro Domain Containing Protein

SPN	Q203
HGNC	29971
MGI	1916308
PubMed	17884105
RGD	1306596
UniProt	Q8WVF1

By cDNA array screening, Nie et al. (2003) identified a transcript that was downregulated in the nasopharyngeal carcinoma cell line HNE-1 relative to normal nasopharyngeal epithelial cells. They assembled the full-length cDNA, designated NOR1, and found that it encodes a deduced 421-amino acid protein with a predicted molecular mass of 48 kD.

The protein contains an oxidored-nitro domain, 2 cAMP and cGMP-dependent protein kinase phosphorylation sites, 5 casein kinase II phosphorylation sites, and 4 N-myristoylation sites. Northern blot analysis detected ubiquitous expression of 1.2- and 1.6-kb transcripts, with highest expression in skeletal muscle and heart.Nie et al. (2003) determined that the NOR1 gene contains 10 exons and spans 33.4 kb.

Reference

"Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE-1 nasopharyngeal carcinoma cell line."
J. Cancer Res. Clin. Oncol. 129:410-414(2003) [PubMed] [Europe PMC] [Abstract]

"Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1."
J. Biol. Chem. 280:32332-32339(2005) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]