Cereblon (CRBN)
MRT2A; Mental Retardation,Non-Syndromic,Autosomal Recessive 2A
Cereblon is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans.
Cereblon forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1), Cullin-4A (CUL4A), and regulator of cullins 1 (ROC1). This complex ubiquitinates a number of other proteins. Through a mechanism which has not been completely elucidated, this ubiquitination results in increased levels of fibroblast growth factor 8 (FGF8). FGF8 in turn regulates a number of developmental processes, such as limb and auditory vesicle formation. The net result is that this ubiquitin ligase complex is important for limb outgrowth in embryos.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | Q124Hu01 | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | MQ124Hu21 | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| PQ124Hu01 | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEQ124Hu | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | Q124Mu01 | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| PQ124Mu01 | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEQ124Mu | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Cereblon (CRBN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Cereblon (CRBN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Cereblon (CRBN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Cereblon (CRBN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Cereblon (CRBN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Cereblon (CRBN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Cereblon (CRBN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Cereblon (CRBN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Cereblon (CRBN) | CLIA assay for Antigen Detection |
Reference
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
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Neurology 63:1927-1931(2004) [PubMed] [Europe PMC] [Abstract]
"Primary function analysis of human mental retardation related gene CRBN."
Mol. Biol. Rep. 35:251-256(2008) [PubMed] [Europe PMC] [Abstract]
"Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation."
Neurogenetics 9:219-223(2008) [PubMed] [Europe PMC] [Abstract]
"Identification of a primary target of thalidomide teratogenicity."
Science 327:1345-1350(2010) [PubMed] [Europe PMC] [Abstract]
"Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)."
Br. J. Haematol. 164:811-821(2014) [PubMed] [Europe PMC] [Abstract]
"Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide."
Nature 512:49-53(2014) [PubMed] [Europe PMC] [Abstract]
"Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs."
Nat. Struct. Mol. Biol. 21:803-809(2014) [PubMed] [Europe PMC] [Abstract]