Chordin Like Protein 1 (CHRDL1)

NRLN1; CHL; VOPT; Ventroptin; Neuralin-1; Neurogenesin-1

SPN	Q113
HGNC	29861
MGI	1933172
PubMed	22284829
UniProt	Q9BU40

In the visual system, the establishment of the anteroposterior and dorsoventral axes in the retina and tectum during development is important for topographic retinotectal projection.

Ventroptin, an antagonist of bone morphogenic protein-4, which is mainly expressed in the ventral retina, not only with a ventral high-dorsal low gradient but also with a nasal high-temporal low gradient at later stages. Misexpression of ventroptin altered expression patterns of several topographic genes in the retina and projection of the retinal axons to the tectum along both axes. Thus, the topographic retinotectal projection appears to be specified by the double-gradient molecule ventroptin along the 2 axes. The chick ventroptin protein contains a putative signal peptide and 3 cysteine-rich repeats.

Reference

"Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis."
Mol. Vis. 14:1138-1148(2008) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"X-linked megalocornea caused by mutations in CHRDL1 identifies an essential role for ventroptin in anterior segment development."
Am. J. Hum. Genet. 90:247-259(2012) [PubMed] [Europe PMC] [Abstract]