Phosphodiesterase 3A, cGMP Inhibited (PDE3A)

CGI-PDE; Cyclic GMP-inhibited phosphodiesterase A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A

SPN	Q099
HGNC	8778
MGI	1860764
PubMed	12154085
RGD	61942
UniProt	Q14432
Wiki	PDE3

Cyclic nucleotide phosphodiesterases (PDEs) comprise a complex group of enzymes, and at least 5 major PDE families or classes with distinctive properties have been identified. Members of the cGMP-inhibited cAMP PDE (cGI-PDE) family, such as PDE3A, are characterized by high affinity for cAMP and cGMP and competitive inhibition of their cAMP hydrolytic activity by cGMP and certain positive inotropic agents .

ORF encodes a predicted protein of 125 kD. A single mRNA species hybridized with a 4-kb EcoRI restriction fragment of the cDNA containing the entire ORF. The C-terminal region of the deduced amino acid sequence contains a putative catalytic domain conserved among mammalian PDE families.

Reference

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