Phosphodiesterase 10A (PDE10A)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

SPN	Q082
HGNC	8772
MGI	1345143
PubMed	21355834
RGD	68434
UniProt	Q9Y233
Wiki	PDE10A

Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.

The deduced 779-amino acid protein has a calculated molecular mass of 88.4 kD and contains cGMP-binding sequences and a catalytic domain. Northern blot analysis detected a 10-kb PDE10A transcript in several tissues, with highest levels in fetal brain and kidney, in putamen and caudate nucleus of adult brain, and in thyroid and testis. A 4-kb transcript was also detected in thyroid and testis. mRNA dot blot analysis showed a similar PDE10A expression pattern.

Reference

"Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP."
Biochem. Biophys. Res. Commun. 261:551-557(1999) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)."
J. Biol. Chem. 274:18438-18445(1999) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of PDE10A, a novel human 3',5'-cyclic nucleotide phosphodiesterase."
Gene 234:109-117(1999) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains."
Eur. J. Biochem. 267:5943-5951(2000) [PubMed] [Europe PMC] [Abstract]

"cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11."
J. Biol. Chem. 281:2841-2846(2006) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Structural insight into substrate specificity of phosphodiesterase 10."
Proc. Natl. Acad. Sci. U.S.A. 104:5782-5787(2007) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP."
J. Biol. Chem. 283:19657-19664(2008) [PubMed] [Europe PMC] [Abstract]