Phosphodiesterase 12 (PDE12)

2'-PDE; 2'-Phosphodiesterase; Mitochondrial deadenylase

SPN	Q080
HGNC	25386
MGI	2443226
PubMed	21666256
RGD	1310975
UniProt	Q6L8Q7

Phosphodiesterase 12 belongs to the CCR4/nocturin family. Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system.

This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Play a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ080Hu01	Recombinant Phosphodiesterase 12 (PDE12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ080Hu01	Monoclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IP.
Antibodies	PAQ080Hu01	Polyclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IF.
Assay Kits	CLQ080Hu01	CLIA Kit for Phosphodiesterase 12 (PDE12)	CLIA assay for Antigen Detection
Assay Kits	ELQ080Hu01	ELISA Kit for Phosphodiesterase 12 (PDE12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ080Mu01	Recombinant Phosphodiesterase 12 (PDE12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ080Mu01	Monoclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IP.
Antibodies	PAQ080Mu01	Polyclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IF.
Assay Kits	CLQ080Mu01	CLIA Kit for Phosphodiesterase 12 (PDE12)	CLIA assay for Antigen Detection
Assay Kits	ELQ080Mu01	ELISA Kit for Phosphodiesterase 12 (PDE12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ080Ra01	Recombinant Phosphodiesterase 12 (PDE12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ080Ra01	Monoclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IP.
Antibodies	PAQ080Ra01	Polyclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IF.
Assay Kits	CLQ080Ra01	CLIA Kit for Phosphodiesterase 12 (PDE12)	CLIA assay for Antigen Detection
Assay Kits	ELQ080Ra01	ELISA Kit for Phosphodiesterase 12 (PDE12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ080Ca01	Recombinant Phosphodiesterase 12 (PDE12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ080Ca01	Monoclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IP.
Antibodies	PAQ080Ca01	Polyclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IF.
Assay Kits	CLQ080Ca01	CLIA Kit for Phosphodiesterase 12 (PDE12)	CLIA assay for Antigen Detection
Assay Kits	ELQ080Ca01	ELISA Kit for Phosphodiesterase 12 (PDE12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ080Po01	Recombinant Phosphodiesterase 12 (PDE12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ080Po01	Monoclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IP.
Antibodies	PAQ080Po01	Polyclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IF.
Assay Kits	CLQ080Po01	CLIA Kit for Phosphodiesterase 12 (PDE12)	CLIA assay for Antigen Detection
Assay Kits	ELQ080Po01	ELISA Kit for Phosphodiesterase 12 (PDE12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ080Bo01	Recombinant Phosphodiesterase 12 (PDE12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ080Bo01	Monoclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IP.
Antibodies	PAQ080Bo01	Polyclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IF.
Assay Kits	CLQ080Bo01	CLIA Kit for Phosphodiesterase 12 (PDE12)	CLIA assay for Antigen Detection
Assay Kits	ELQ080Bo01	ELISA Kit for Phosphodiesterase 12 (PDE12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ080Rb01	Recombinant Phosphodiesterase 12 (PDE12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ080Rb01	Monoclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IP.
Antibodies	PAQ080Rb01	Polyclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IF.
Assay Kits	CLQ080Rb01	CLIA Kit for Phosphodiesterase 12 (PDE12)	CLIA assay for Antigen Detection
Assay Kits	ELQ080Rb01	ELISA Kit for Phosphodiesterase 12 (PDE12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPQ080Mo01	Recombinant Phosphodiesterase 12 (PDE12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAQ080Mo01	Monoclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IP.
Antibodies	PAQ080Mo01	Polyclonal Antibody to Phosphodiesterase 12 (PDE12)	WB; IHC; ICC; IF.
Assay Kits	CLQ080Mo01	CLIA Kit for Phosphodiesterase 12 (PDE12)	CLIA assay for Antigen Detection
Assay Kits	ELQ080Mo01	ELISA Kit for Phosphodiesterase 12 (PDE12)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon."
J. Biol. Chem. 279:37832-37841(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover."
Nucleic Acids Res. 39:3754-3770(2011) [PubMed] [Europe PMC] [Abstract]

"PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria."
Nucleic Acids Res. 39:7750-7763(2011) [PubMed] [Europe PMC] [Abstract]

"Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1."
Biochimie 94:1098-1107(2012) [PubMed] [Europe PMC] [Abstract]