Myopalladin (MYPN)
MYOP; Sarcomeric Protein Myopalladin,145 kDa
MYPN is a component of the sarcomere that tethers nebulin in skeletal muscle and nebulette in cardiac muscle to alpha-actinin at the Z lines.
The deduced 1,320-amino acid protein has a calculated molecular mass of 145 kD. It contains 5 immunoglobulin (Ig) repeats and 6 interdomain insertions. RNA dot blot analysis of multiple human tissues detected expression restricted to adult skeletal muscle and adult and fetal heart; fetal skeletal muscle was not examined. Immunofluorescent staining revealed that rat Mypn localized at the Z line of both heart and skeletal myofibrils, and it colocalized with cardiac ankyrin repeat protein (Carp) within the I band. Mypn localized to the nucleus in about 75% of isolated rat cardiac myocytes.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | Q075Hu01 | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | MQ075Hu21 | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| PQ075Hu01 | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEQ075Hu | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Myopalladin (MYPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Myopalladin (MYPN) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Myopalladin (MYPN) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Myopalladin (MYPN) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Myopalladin (MYPN) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Myopalladin (MYPN) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Myopalladin (MYPN) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Myopalladin (MYPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Myopalladin (MYPN) | CLIA assay for Antigen Detection |
Reference
"Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies."
J. Cell Biol. 153:413-427(2001) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin."
FEBS Lett. 532:273-278(2002) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations."
Hum. Mol. Genet. 21:2039-2053(2012) [PubMed] [Europe PMC] [Abstract]
"Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy."
Cardiovasc. Res. 77:118-125(2008) [PubMed] [Europe PMC] [Abstract]
"Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy."
Eur. J. Hum. Genet. 21:294-300(2013) [PubMed] [Europe PMC] [Abstract]