Free Fatty Acid Receptor 4 (FFAR4)

GPR129; GT01; PGR4; GPR120; O3FAR1; G Protein Coupled Receptor 120; Omega-3 fatty acid receptor 1

SPN	Q062
HGNC	19061
MGI	2147577
PubMed	22343897
RGD	1308252
UniProt	Q5NUL3
Wiki	GPR120

GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs).The deduced 377-amino acid protein assumes a classic 7-transmembrane (TM) topology and contains an NSxxNPxxY motif in TM7. In place of the DRY motif in the intracellular side of TM3, GPR120 contains an ERM motif. GPR120 shares 86% amino acid identity with mouse Gpr120. EST database analysis indicated that GPR120 is expressed in stomach.

GPR120 highest expression in lung, followed by colon, rectum, and ileum. Lower expression was detected in adrenal gland, brain, and thymus, and no expression was detected in other tissues and specific intestinal regions examined. Mouse tissues showed a similar but slightly broader expression profile.

Reference

"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]

"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120."
Nat. Med. 11:90-94(2005) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The G protein-coupled receptor repertoires of human and mouse."
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]

"The regulation of adipogenesis through GPR120."
Biochem. Biophys. Res. Commun. 354:591-597(2007) [PubMed] [Europe PMC] [Abstract]

"Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor."
Biochem. Biophys. Res. Commun. 396:1030-1035(2010) [PubMed] [Europe PMC] [Abstract]

"Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human."
Nature 483:350-354(2012) [PubMed] [Europe PMC] [Abstract]