G Protein Coupled Receptor 172A (GPR172A)

SLC52A2; PAR1; GPCR41; RFT3; Porcine endogenous retrovirus A receptor 1; Riboflavin transporter 3; Solute carrier family 52, riboflavin transporter, member 2

SPN	Q045
HGNC	30224
MGI	1289288
PubMed	23506902
UniProt	Q9HAB3
Wiki	GPR172A

GPCR41 and GPCR42 act as receptors for porcine endogenous retrovirus subgroup A (PERV-A).The deduced 445-amino acid protein is a putative G protein-coupled receptor and contains 10 or 11 putative transmembrane regions similar to other gammaretrovirus receptors. PAR1 shares significant homology with PAR2 and with PAR proteins from baboon, pig, and mouse. Northern blot analysis using a probe that did not differentiate between PAR1 and PAR2 detected expression in all tissues examined, with the possible exception of bladder. Highest expression was in testis. RT-PCR detected PAR1 and PAR2 expression in peripheral blood mononuclear cells of 11 healthy volunteers.Expression of PAR1 and PAR2 did not alter the sensitivity of the rabbit cells to PERV-B or -C. The results suggested that PAR2 may mediate a higher level of PERV infection than PAR1.

Reference

"Identification of receptors for pig endogenous retrovirus."
Proc. Natl. Acad. Sci. U.S.A. 100:6759-6764(2003) [PubMed] [Europe PMC] [Abstract]

"Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain."
J. Nutr. 140:1220-1226(2010) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor."
Proc. Natl. Acad. Sci. U.S.A. 106:5848-5853(2009) [PubMed] [Europe PMC] [Abstract]

"Exome sequencing reveals riboflavin transporter mutations as a cause of motor neuron disease."
Brain 135:2875-2882(2012) [PubMed] [Europe PMC] [Abstract]