G Protein Coupled Receptor 37 (GPR37)

EDNRBL; PAELR; hET(B)R-LP; Endothelin Receptor Type B-Like; Parkin-associated endothelin receptor-like receptor; Prosaposin receptor GPR37

SPN	Q039
HGNC	4494
MGI	1313297
PubMed	23398388
RGD	619848
UniProt	O15354
Wiki	GPR37

GPR37, a predicted 613-amino acid protein with 7 hydrophobic domains and significant similarity to GPCRs. The authors isolated the genomic sequence of GPR37 and found that it is composed of 2 exons and spans approximately 25 kb. GPR37 is expressed in brain as a major 3.8-kb mRNA and a less abundant 8-kb mRNA; the 3.8-kb mRNA is also detected in liver and placenta. The GPR37 protein is 27% identical to EDNRB. In situ hybridization and reverse transcriptase in situ gene amplification showed that GPR37 mRNA is particularly concentrated in Purkinje cells of the cerebellum and in neuronal cells of the hippocampus. Functional assays indicated that endothelin-1 (EDN1), endothelin-3 (EDN3), bombesin, and neuropeptide Y (NPY) did not have an effect on mammalian cells expressing recombinant GPR37.

Reference

"Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library."
Genomics 45:68-77(1997) [PubMed] [Europe PMC] [Abstract]

"A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system."
Brain Res. Mol. Brain Res. 54:152-160(1998) [PubMed] [Europe PMC] [Abstract]

"A novel endothelin receptor type-B-like gene enriched in the brain."
Biochem. Biophys. Res. Commun. 233:559-567(1997) [PubMed] [Europe PMC] [Abstract]

"An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin."
Cell 105:891-902(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity."
Mol. Cell 10:55-67(2002) [PubMed] [Europe PMC] [Abstract]

"A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."
J. Biol. Chem. 278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]

"A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin."
J. Neurochem. 99:1456-1469(2006) [PubMed] [Europe PMC] [Abstract]

"GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin."
Proc. Natl. Acad. Sci. U.S.A. 110:9529-9534(2013) [PubMed] [Europe PMC] [Abstract]