TNF Receptor Associated Factor 6 (TRAF6)

RNF85; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer

SPN	P998
HGNC	12036
MGI	108072
PubMed	24492375
RGD	1306853
UniProt	Q9Y4K3
Wiki	TRAF6

TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.

Reference

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Submitted (MAR-2008) to the PDB data bank

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