Crk Like Protein (CRKL)
V-Crk Sarcoma Virus CT10 Oncogene Homolog(avian)-Like
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL.
In addition, CRKL has oncogenic potential.CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.CRKL becomes phosphorylated when overexpressed, activates Ras-dependent and JNK pathways, and transforms fibroblasts. The authors also found CRKL to be a substrate for the BCR-ABL tyrosine kinase (ABL), leading them to conclude that CRKL is a tyrosine kinase and an oncogene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | P983Hu01 | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | MP983Hu21 | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| PP983Hu01 | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | P983Mu01 | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| PP983Mu01 | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Crk Like Protein (CRKL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Crk Like Protein (CRKL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Crk Like Protein (CRKL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Crk Like Protein (CRKL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Crk Like Protein (CRKL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Crk Like Protein (CRKL) | CLIA assay for Antigen Detection |
Reference
"Isolation and chromosomal localization of CRKL, a human crk-like gene."
Oncogene 8:2469-2474(1993) [PubMed] [Europe PMC] [Abstract]
"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction."
J. Biol. Chem. 273:14780-14787(1998) [PubMed] [Europe PMC] [Abstract]
"Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation."
Oncogene 18:1147-1156(1999) [PubMed] [Europe PMC] [Abstract]
"DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines."
Blood 100:3968-3974(2002) [PubMed] [Europe PMC] [Abstract]
"CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling."
J. Biol. Chem. 276:33282-33290(2001) [PubMed] [Europe PMC] [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structures of the SH3 domain of human CRK-like protein."
Submitted (DEC-2006) to the PDB data bank