Breast Cancer Anti-Estrogen Resistance 1 (BCAR1)

CAS; CRKAS; P130Cas; CASS1; Crk-Associated Substrate; Cas Scaffolding Protein Family Member 1

SPN	P980
HGNC	971
MGI	108091
PubMed	22241677
RGD	2406
UniProt	P56945
Wiki	BCAR1

BCAR1, or CAS, is an Src family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion. The predicted 870-amino acid BCAR1 protein has a calculated mass of 93 kD. BCAR1 contains an SH3 domain in its N-terminal part, multiple potential tyrosine phosphorylation sites in its central part, and a proline-rich stretch in its C-terminal part.

BCAR1 shares 91% amino acid identity with rat and mouse p130Cas. SDS-PAGE and Western blot analyses demonstrated that BCAR1 encodes a 116-kD protein; the mouse and rodent p130Cas proteins exhibit the same size. BCAR1 transcript in all tissues tested, with highest expression in testis and low expression in liver, thymus, and peripheral blood leukocytes.

Reference

"BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells."
J. Natl. Cancer Inst. 92:112-120(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]