NK3 Homeobox Protein 1 (NKX3-1)

BAPX2; NKX3; NKX3.1; NKX3A; NK3 transcription factor related, locus 1; Homeobox protein NK-3 homolog A

SPN	P968
HGNC	7838
MGI	97352
PubMed	20588175
RGD	1305369
UniProt	Q99801
Wiki	NKX3-1

The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.

NKX3.1, encodes a deduced 234-amino acid polypeptide with greatest homology to the Drosophila NK3 gene. Northern blot analysis showed that NKX3.1 had a uniquely restricted tissue expression pattern. The 3.5-kb NKX3.1 mRNA was abundant in the prostate, present at a lower level in the testis, and absent from all other tissues tested. Androgen stimulation markedly increased NKX3.1 expression in an androgen-dependent carcinoma line.

Reference

"A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer."
Genomics 43:69-77(1997) [PubMed] [Europe PMC] [Abstract]

"Isolation and androgen regulation of the human homeobox cDNA, NKX3.1."
Prostate 35:71-80(1998) [PubMed] [Europe PMC] [Abstract]

"Full-length cDNA sequence and genomic organization of human NKX3A --alternative mRNA forms and regulation by both androgens and estrogens."
Gene 260:25-36(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter."
Cancer Res. 62:338-340(2002) [PubMed] [Europe PMC] [Abstract]

"Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription."
Mol. Cell. Biol. 23:7019-7029(2003) [PubMed] [Europe PMC] [Abstract]

"Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1."
J. Biol. Chem. 283:4834-4840(2008) [PubMed] [Europe PMC] [Abstract]

"Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1."
Mol. Biol. Rep. 37:1505-1512(2010) [PubMed] [Europe PMC] [Abstract]

"Solution NMR structure of homeobox domain of homeobox protein NKX-3.1 from Homo sapiens, Northeast structural genomics consortium target HR6470A."
Submitted (APR-2011) to the PDB data bank

"Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers."
Cancer Res. 57:4455-4459(1997) [PubMed] [Europe PMC] [Abstract]

Erratum
Cancer Res. 57:5613-5613(1997)