Polo Like Kinase 3 (PLK3)

CNK; FNK; PRK; Cytokine-Inducible Kinase; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Proliferation-related kinase

SPN	P963
HGNC	2154
MGI	109604
PubMed	11551930
RGD	62039
UniProt	Q9H4B4
Wiki	PLK3

CNK is a member of the 'polo' family of serine/threonine kinases. Members of this family have been implicated in cell division and are important in regulating the onset of mitosis and M-phase progression.The predicted 607-amino acid protein has an N-terminal catalytic domain, including an ATP-binding site, a central putative nuclear targeting signal, and a presumed C-terminal regulatory domain. The CNK protein shows homology with several other members of the 'polo' family; it is 91% identical to mouse Fnk, 50% identical to human PLK, 48% identical to Drosophila polo, and 38% identical to S. cerevisiae Cdc5. Northern blot analysis detected expression of a 2.5-kb CNK transcript in a limited number of human tissues, with placenta containing a moderate level and ovary, lung, and peripheral blood leukocytes containing low levels.

Reference

"Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages."
Oncogene 19:4832-4839(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas."
J. Biol. Chem. 271:19402-19408(1996) [PubMed] [Europe PMC] [Abstract]

"Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines."
Genes Chromosomes Cancer 32:384-389(2001) [PubMed] [Europe PMC] [Abstract]

"Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways."
Oncogene 21:6633-6640(2002) [PubMed] [Europe PMC] [Abstract]

"Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions."
J. Biol. Chem. 272:28646-28651(1997) [PubMed] [Europe PMC] [Abstract]

"The physical association and phosphorylation of Cdc25C protein phosphatase by Prk."
Oncogene 18:6029-6036(1999) [PubMed] [Europe PMC] [Abstract]

"Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3."
Cancer Res. 60:6826-6831(2000) [PubMed] [Europe PMC] [Abstract]

"Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3."
J. Biol. Chem. 276:36194-36199(2001) [PubMed] [Europe PMC] [Abstract]

"Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway."
J. Biol. Chem. 276:43305-43312(2001) [PubMed] [Europe PMC] [Abstract]

"Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity."
Mol. Cell. Biol. 22:3450-3459(2002) [PubMed] [Europe PMC] [Abstract]

"Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle."
Exp. Cell Res. 294:51-59(2004) [PubMed] [Europe PMC] [Abstract]

"Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation."
Oncogene 23:2658-2663(2004) [PubMed] [Europe PMC] [Abstract]

"MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3."
Oncogene 23:3822-3829(2004) [PubMed] [Europe PMC] [Abstract]

"Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis."
J. Biol. Chem. 281:10577-10582(2006) [PubMed] [Europe PMC] [Abstract]

"Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage."
Mutat. Res. 596:166-176(2006) [PubMed] [Europe PMC] [Abstract]

"Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells."
J. Biol. Chem. 282:32121-32127(2007) [PubMed] [Europe PMC] [Abstract]

"Polo-like kinase 3 is required for entry into S phase."
Proc. Natl. Acad. Sci. U.S.A. 104:1847-1852(2007) [PubMed] [Europe PMC] [Abstract]

"Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1."
Biochem. J. 411:27-32(2008) [PubMed] [Europe PMC] [Abstract]

"Activation of Polo-like kinase 3 by hypoxic stresses."
J. Biol. Chem. 283:25928-25935(2008) [PubMed] [Europe PMC] [Abstract]

"Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation."
Genes Cells 14:775-788(2009) [PubMed] [Europe PMC] [Abstract]

"Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation."
Mol. Cell. Biol. 29:1189-1201(2009) [PubMed] [Europe PMC] [Abstract]

"Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha."
J. Biol. Chem. 285:38944-38950(2010) [PubMed] [Europe PMC] [Abstract]

"Regulation of PTEN stability and activity by Plk3."
J. Biol. Chem. 285:39935-39942(2010) [PubMed] [Europe PMC] [Abstract]

"Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression."
Int. J. Biochem. Cell Biol. 43:120-129(2011) [PubMed] [Europe PMC] [Abstract]

"Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells."
Int. J. Cancer 128:587-596(2011) [PubMed] [Europe PMC] [Abstract]

"Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells."
J. Biol. Chem. 286:1951-1958(2011) [PubMed] [Europe PMC] [Abstract]

"Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints."
Cell. Signal. 23:2030-2038(2011) [PubMed] [Europe PMC] [Abstract]

"Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors."
Mutat. Res. 714:1-10(2011) [PubMed] [Europe PMC] [Abstract]

"Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells."
PLoS ONE 6:E14513-E14513(2011) [PubMed] [Europe PMC] [Abstract]

"Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy."
Nat. Rev. Drug Discov. 9:643-660(2010) [PubMed] [Europe PMC] [Abstract]