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Transcobalamin I (TCN1)
Transcobalamin I (TCN1)
TCI; TC1; Haptocorin; Haptocorrin; Vitamin B12 Binding Protein,R Binder Family
There are 3 types of human vitamin B12-binding proteins: gastric intrinsic factor (GIF), also known as transcobalamin III; plasma transcobalamin II (TCN2); and transcobalamin I (TCN1), an R binder protein. R binder proteins are a class of immunologically identical but electrophoretically distinct glycoproteins found in many secretions, such as saliva, gastric juice, tears, milk and leukocytes, and differ only in their carbohydrate content; 'R' denotes 'rapid,' referring to electrophoretic mobility. Transcobalamin I is also found in neutrophils, where it is restricted to the secondary granules.
The deduced 433-residue protein showed extensive areas of homology with rat gastric intrinsic factor, which implicated regions potentially important for vitamin B12 binding.Comparison of the genomic structures of TCN1 and GIF suggested that the 2 genes arose by a gene duplication.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
P953Hu01
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
MP953Hu21
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
PP953Hu01
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
KEP953Hu
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Transcobalamin I (TCN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Transcobalamin I (TCN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Transcobalamin I (TCN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Transcobalamin I (TCN1) CLIA assay for Antigen Detection
Reference
"Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein." PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed ] [Europe PMC ] [Abstract ]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." J. Proteome Res. 4:2070-2080(2005) [PubMed ] [Europe PMC ] [Abstract ]
"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry." J. Proteome Res. 5:1493-1503(2006) [PubMed ] [Europe PMC ] [Abstract ]
"Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin." J. Biol. Chem. 288:25466-25476(2013) [PubMed ] [Europe PMC ] [Abstract ]
