Lysine Specific Demethylase 4C (KDM4C)
JMJD2C; JHDM3C; GASC1; Jumonji Domain Containing 2C; Gene amplified in squamous cell carcinoma 1 protein; JmjC domain-containing histone demethylation protein 3C
KDM4C encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.The transcript contains an MIR repetitive element in its 3-prime UTR, and the deduced 1,100-amino acid protein shares significant similarity with an S. cerevisiae zinc finger protein. RT-PCR ELISA detected JMJD2C expression in all tissues examined. Highest expression was in brain, and lowest was in skeletal muscle and spleen.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP939Hu01 | Recombinant Lysine Specific Demethylase 4C (KDM4C) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP939Hu01 | Monoclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IP. |
| PAP939Hu01 | Polyclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP939Hu01 | CLIA Kit for Lysine Specific Demethylase 4C (KDM4C) | CLIA assay for Antigen Detection |
| ELP939Hu01 | ELISA Kit for Lysine Specific Demethylase 4C (KDM4C) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP939Mu01 | Recombinant Lysine Specific Demethylase 4C (KDM4C) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP939Mu01 | Monoclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IP. |
| PAP939Mu01 | Polyclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP939Mu01 | CLIA Kit for Lysine Specific Demethylase 4C (KDM4C) | CLIA assay for Antigen Detection |
| ELP939Mu01 | ELISA Kit for Lysine Specific Demethylase 4C (KDM4C) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP939Ra01 | Recombinant Lysine Specific Demethylase 4C (KDM4C) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP939Ra01 | Monoclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IP. |
| PAP939Ra01 | Polyclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP939Ra01 | CLIA Kit for Lysine Specific Demethylase 4C (KDM4C) | CLIA assay for Antigen Detection |
| ELP939Ra01 | ELISA Kit for Lysine Specific Demethylase 4C (KDM4C) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP939Ca01 | Recombinant Lysine Specific Demethylase 4C (KDM4C) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP939Ca01 | Monoclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IP. |
| PAP939Ca01 | Polyclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP939Ca01 | CLIA Kit for Lysine Specific Demethylase 4C (KDM4C) | CLIA assay for Antigen Detection |
| ELP939Ca01 | ELISA Kit for Lysine Specific Demethylase 4C (KDM4C) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP939Po01 | Recombinant Lysine Specific Demethylase 4C (KDM4C) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP939Po01 | Monoclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IP. |
| PAP939Po01 | Polyclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP939Po01 | CLIA Kit for Lysine Specific Demethylase 4C (KDM4C) | CLIA assay for Antigen Detection |
| ELP939Po01 | ELISA Kit for Lysine Specific Demethylase 4C (KDM4C) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP939Bo01 | Recombinant Lysine Specific Demethylase 4C (KDM4C) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP939Bo01 | Monoclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IP. |
| PAP939Bo01 | Polyclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP939Bo01 | CLIA Kit for Lysine Specific Demethylase 4C (KDM4C) | CLIA assay for Antigen Detection |
| ELP939Bo01 | ELISA Kit for Lysine Specific Demethylase 4C (KDM4C) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP939Rb01 | Recombinant Lysine Specific Demethylase 4C (KDM4C) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP939Rb01 | Monoclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IP. |
| PAP939Rb01 | Polyclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP939Rb01 | CLIA Kit for Lysine Specific Demethylase 4C (KDM4C) | CLIA assay for Antigen Detection |
| ELP939Rb01 | ELISA Kit for Lysine Specific Demethylase 4C (KDM4C) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP939Mo01 | Recombinant Lysine Specific Demethylase 4C (KDM4C) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP939Mo01 | Monoclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IP. |
| PAP939Mo01 | Polyclonal Antibody to Lysine Specific Demethylase 4C (KDM4C) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP939Mo01 | CLIA Kit for Lysine Specific Demethylase 4C (KDM4C) | CLIA assay for Antigen Detection |
| ELP939Mo01 | ELISA Kit for Lysine Specific Demethylase 4C (KDM4C) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Cell 125:467-481(2006) [PubMed] [Europe PMC] [Abstract]
"Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family."
J. Biol. Chem. 286:41616-41625(2011) [PubMed] [Europe PMC] [Abstract]