WNK Lysine Deficient Protein Kinase 1 (WNK1)

HSN2; KDP; PHA2C; PRKWNK1; HSAN2; Protein Kinase,Lysine Deficient 1; Hereditary Sensory Neuropathy, Type II; Erythrocyte 65 kDa protein; Kinase deficient protein

SPN	P854
HGNC	14540
MGI	2442092
PubMed	23250415
RGD	621141
UniProt	Q9H4A3
Wiki	WNK1

The WNK1 protein is composed of 2382 amino acids. The protein contains a small N-terminal domain followed by the kinase domain and a long C-terminal tail. The kinase domain has some similarity to the MEKK protein kinase family.

The protein appears to be part of the ERK5 MAP kinase pathway upstream of MEKK2 / MEKK3 and to function as a tetramer. It selectively binds to and phosphorylates synaptotagmin 2 (SYT2) within its calcium binding C2 domains. It activates the serum- and glucocorticoid-inducible protein kinase SGK1, leading to activation of the epithelial sodium channel. It along with WNK4 stimulates clathrin-dependent endocytosis of renal outer medullar potassium 1 (ROMK1). It (and WNK4) interactes with intersectin (ITSN1, ITSN2).

Reference

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