WNT1 Inducible Signaling Pathway Protein 1 (WISP1)
CCN4; WISP1c; WISP1i; WISP1tc; CCN family member 4; Wnt-1-induced secreted protein
WISP1 encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP851Hu01 | Recombinant WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP851Hu01 | Monoclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IP. |
| PAP851Hu01 | Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP851Hu01 | CLIA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | CLIA assay for Antigen Detection |
| ELP851Hu01 | ELISA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP851Mu01 | Recombinant WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP851Mu01 | Monoclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IP. |
| PAP851Mu01 | Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP851Mu01 | CLIA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | CLIA assay for Antigen Detection |
| ELP851Mu01 | ELISA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP851Ra01 | Recombinant WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP851Ra01 | Monoclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IP. |
| PAP851Ra01 | Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP851Ra01 | CLIA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | CLIA assay for Antigen Detection |
| ELP851Ra01 | ELISA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP851Ca01 | Recombinant WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP851Ca01 | Monoclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IP. |
| PAP851Ca01 | Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP851Ca01 | CLIA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | CLIA assay for Antigen Detection |
| ELP851Ca01 | ELISA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP851Po01 | Recombinant WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP851Po01 | Monoclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IP. |
| PAP851Po01 | Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP851Po01 | CLIA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | CLIA assay for Antigen Detection |
| ELP851Po01 | ELISA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP851Bo01 | Recombinant WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP851Bo01 | Monoclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IP. |
| PAP851Bo01 | Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP851Bo01 | CLIA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | CLIA assay for Antigen Detection |
| ELP851Bo01 | ELISA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP851Rb01 | Recombinant WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP851Rb01 | Monoclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IP. |
| PAP851Rb01 | Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP851Rb01 | CLIA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | CLIA assay for Antigen Detection |
| ELP851Rb01 | ELISA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP851Mo01 | Recombinant WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP851Mo01 | Monoclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IP. |
| PAP851Mo01 | Polyclonal Antibody to WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP851Mo01 | CLIA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | CLIA assay for Antigen Detection |
| ELP851Mo01 | ELISA Kit for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
"A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma."
Oncogene 20:5525-5532(2001) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene."
Genes Dev. 14:585-595(2000) [PubMed] [Europe PMC] [Abstract]
"WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase."
Genes Dev. 16:46-57(2002) [PubMed] [Europe PMC] [Abstract]
"WISP-1 binds to decorin and biglycan."
J. Biol. Chem. 276:47599-47607(2001) [PubMed] [Europe PMC] [Abstract]