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Ubiquilin 2 (UBQLN2)

CHAP1; CHAP1/DSK2; Dsk2; LIC-2; N4BP4; PLIC-2; PLIC2; NEDD4 Binding Protein 4; Protein linking IAP with cytoskeleton 2; Ubiquitin-like product Chap1/Dsk2

Ubiquilin-2 is a ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. The predicted 624-amino acid PLIC2 protein, also called UBQLN2, shares 72% amino acid identity with PLIC1. Two motifs are conserved in the mammalian PLICs and yeast Dsk2, an N-terminal ubiquitin-like (UBL) domain and a C-terminal ubiquitin-associated (UBA) domain.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins P798Hu01 Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies MP798Hu21 Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
PP798Hu01 Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits KEP798Hu ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquilin 2 (UBQLN2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquilin 2 (UBQLN2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquilin 2 (UBQLN2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquilin 2 (UBQLN2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquilin 2 (UBQLN2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquilin 2 (UBQLN2) CLIA assay for Antigen Detection

Reference

"A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch."
FEBS Lett. 467:348-355(2000) [PubMed] [Europe PMC] [Abstract]

"The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome."
Mol. Cell 6:409-419(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Selection system for genes encoding nuclear-targeted proteins."
Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking."
Hum. Mol. Genet. 23:3579-3595(2014) [PubMed] [Europe PMC] [Abstract]

"Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a."
Biochemistry 41:1767-1777(2002) [PubMed] [Europe PMC] [Abstract]

"Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia."
Nature 477:211-215(2011) [PubMed] [Europe PMC] [Abstract]

"Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype."
Neurobiol. Aging 33:E13-E17(2012) [PubMed] [Europe PMC] [Abstract]

"UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis."
Neurobiol. Aging 33:E3-E10(2012) [PubMed] [Europe PMC] [Abstract]

"UBQLN2 mutations are rare in French and French-Canadian amyotrophic lateral sclerosis."
Neurobiol. Aging 33:E1-E5(2012) [PubMed] [Europe PMC] [Abstract]

"ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1."
Hum. Mol. Genet. 24:2565-2577(2015) [PubMed] [Europe PMC] [Abstract]