TXK Tyrosine Kinase (TXK)

BTKL; PSCTK5; PTK4; RLK; TKL; PTK4 Protein Tyrosine Kinase 4; Resting lymphocyte kinase

SPN	P762
HGNC	12434
MGI	102960
PubMed	7951233
RGD	1306481
UniProt	P42681
Wiki	TXK

The complete nucleotide sequence of the cDNA indicated that it was related most closely to EMT, a tyrosine kinase of T cells, and to the B-cell tyrosine kinase BTK, which is mutated in X-linked agammaglobulinemia in humans and X-linked immunodeficiency disease (XID) in mice. Other members of this gene family include BMX and TEC.

TXK, like BTK, is a member of the TEC subfamily of SRC-type (nonreceptor) tyrosine kinases. Like other members of the TEC subfamily, and unlike other SRC kinases, TXK lacks both the N-terminal myristylation signal and the C-terminal regulatory tyrosine. TXK expression is detected primarily in T cells and some myeloid cell lines, but not in a number of other cell types.

Reference

"TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12."
Hum. Mol. Genet. 3:897-901(1994) [PubMed] [Europe PMC] [Abstract]

"Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene."
Oncogene 12:937-942(1996) [PubMed] [Europe PMC] [Abstract]

"Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4."
Biochem. Biophys. Res. Commun. 252:14-19(1998) [PubMed] [Europe PMC] [Abstract]

"Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes."
J. Exp. Med. 190:1147-1154(1999) [PubMed] [Europe PMC] [Abstract]

"Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes."
Mol. Cell. Biol. 21:6939-6950(2001) [PubMed] [Europe PMC] [Abstract]

"Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site."
Biol. Pharm. Bull. 25:718-721(2002) [PubMed] [Europe PMC] [Abstract]

"Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription."
J. Immunol. 168:2365-2370(2002) [PubMed] [Europe PMC] [Abstract]

"Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells."
Clin. Exp. Immunol. 147:164-175(2007) [PubMed] [Europe PMC] [Abstract]

"Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk."
Immunol. Rev. 228:93-114(2009) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the SH2 domain of human tyrosine-protein kinase TXK."
Submitted (OCT-2006) to the PDB data bank

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]